introduction aortic surgery has made much progress recently. yet the combination of aortic surgery and coronary artery bypass grafting has remained a major issue for the surgeons. patient and observation herein, we present a case of severe aortic insufficiency with aortic aneurysm concomitant with single coronary artery disease on the right coronary artery. the patient underwent bentall procedu...

transcatheter aortic valve replacement (tavr) is a novel therapeutic intervention for the replacement of severely stenotic aortic valves in high-risk patients for standard surgical procedures. since the initial partner trial results, use of tavr has been on the rise each year. new delivery methods and different valves have been developed and modified in order to promote the minimally invasive p...

Objective: This study evaluated the possible protective effect of valenoic acid dilactone on fludrocortisones induced hypertension in Wister rats. Methodology: Fludrocortisones induced reabsorption of salt and water leading to increase in blood volume and hence, increase blood pressure. There is also increased secretion of vasopressin in addition, altered activity of renninangiotensin-aldostero...

Vascular reactivity was evaluated in three separate arteries isolated from rats after angiotensin II (Ang II) was infused chronically in two separate experiments, one using a 14-day high, slow-pressor dose known to produce hypertension and the other using a 7-day low, subpressor but hypertensive-sensitizing dose. There were three new findings. First, there was no evidence of altered vascular re...

Most vaso-reactive studies in mouse aortic segments are performed in isometric conditions and at an optimal preload, which is the preload corresponding to a maximal contraction by non-receptor or receptor-mediated stimulation. In general, this optimal preload ranges from about 1.2 to 8.0 mN/mm, which according to Laplace's law roughly correlates with transmural pressures of 10-65 mmHg. For phys...

The aim of this study was to determine whether the effects of hypoxia on aortic contractility reflect a decrease in smooth muscle activation [phosphorylation of the 20-kDa myosin regulatory light chain (LC(20))], the capacity for myofibrillar ATP hydrolysis (mATPase activity), or both. Our results indicate that, in endothelium-denuded aortic rings from rats exposed to hypoxia for 48 h (inspired...

Exercise is known to cause a vasodilatory response; however, the correlation between the vasorelaxant response and different training intensities has not been investigated. Therefore, this study evaluated the vascular reactivity and lipid peroxidation after different intensities of swimming exercise in rats. Male Wistar rats (aged 8 weeks; 250-300 g) underwent forced swimming for 1 h whilst tie...