The number of chemicals for which environmental regulatory decisions are required far exceeds the current capacity for toxicity testing. High-throughput screening commonly used for drug discovery has the potential to increase this capacity. The adverse outcome pathway (AOP) concept has emerged as a framework for connecting high-throughput toxicity testing (HTT) and other results to potential im...

AOP [1] has been proposed as a way to write programs that elegantly implement crosscutting concerns. This paper presents initial results of an exploration into whether this is true for AspectJ [2]. During this this exploration we have written several small and medium scale systems using AspectJ. Writing elegant code requires good implementation structure. This paper presents some of the more in...

Apnea of prematurity (AOP) is considered a risk factor for neurodevelopmental disorders in children based on epidemiological studies. This idea is supported by studies in newborn rodents in which exposure to intermittent hypoxia (IH) as a model of AOP significantly impairs development. However, the severe IH used in these studies may not fully reflect the broad spectrum of AOP severity. Conside...

Aspect oriented programming AOP controls tangling of concerns by isolating aspects that cross cut each other into building blocks Component based programming CBP supports software development by isolating reusable building blocks that can be assembled and connected in many di erent ways We show how AOP and CBP can be integrated by introducing a new component construct for programming class coll...

Aspect-oriented programming (AOP) is an emerging technique that provides a mechanism to clearly encapsulate and implement concerns that crosscut other modules. It is claimed that this technique improves code modularization and therefore reduces complexity of object-oriented programs (OOP). Most of the proposed complexity measurement frameworks for AOP are for AspectJ programming language. In th...

We describe the Aspect Markup Language (AML), an XML-based AOP language for programming aspects. AML separates the binding instructions, written in XML, from the executable aspect code, written in a regular programming language. This separation by itself has some advantages, namely for testing. But the main goal of AML is to provide a highly extensible AOP platform, with which programmers can e...

Normally, Aspect-Oriented Programming (AOP) is used for plugging and not for unplugging. Aspects (concerns) are weaved into a system, thus providing a modularized way to add crosscutting features to a base program. For example, given a base program without logging and given a logging aspect, the AOP weaver produces from the untangled code an executable with the desired crosscutting logging beha...

Aspect-oriented programming (AOP) seeks to improve software modularity via the separation of cross-cutting concerns. AOP proponents often advocate a development strategy where programmers write the main application (base code), ignoring cross-cutting concerns, and then aspect programmers, domain experts in their specific concerns, weave in the logic for these more specialized cross-cutting conc...

PURPOSE To compare the visual performance of prototype contact lenses designed via deliberate manipulation of higher-order spherical aberrations to extend-depth-of-focus with two commercial multifocals, after 1 week of lens wear. METHODS In a prospective, participant-masked, cross-over, randomized, 1-week dispensing clinical-trial, 43 presbyopes [age: 42-63 years] each wore AIROPTIX Aqua mult...