نتایج جستجو برای: antivirulence agents
تعداد نتایج: 360788 فیلتر نتایج به سال:
Many Proteobacteria use N-acyl-homoserine lactone (acyl-HSL) quorum sensing to control specific genes. Acyl-HSL synthesis requires unique enzymes that use S-adenosyl methionine as an acyl acceptor and amino acid donor. We developed and executed an enzyme-coupled high-throughput cell-free screen to discover acyl-HSL synthase inhibitors. The three strongest inhibitors were equally active against ...
Pyocyanin is a small molecule produced by Pseudomonas aeruginosa that plays a crucial role in the pathogenesis of infections by this notorious opportunistic pathogen. The inhibition of pyocyanin production has been identified as an attractive antivirulence strategy for the treatment of P. aeruginosa infections. Herein, we report the discovery of an inhibitor of pyocyanin production in cultures ...
In Pseudomonas aeruginosa, the quorum-sensing (QS) system is closely related to biofilm formation. We previously demonstrated that 14-alpha-lipoyl andrographolide (AL-1) has synergistic effects on antibiofilm and antivirulence factors (pyocyanin and exopolysaccharide) of P. aeruginosa when combined with conventional antibiotics, while it has little inhibitory effect on its growth. However, its ...
Antibiotics are still critically important as a first line therapy for the treatment of various bacterial infections in the clinic. In addition to their use in human medicine, these compounds have also been used for decades in animal production, for both growth promotion and veterinary purposes [1,2]. Because of the development and spread of antibiotic resistance, there is a growing awareness t...
The need for novel antibacterial strategies and the awareness of the importance of quorum sensing (QS) in bacterial infections have stimulated research aimed at identifying QS inhibitors (QSIs). However, clinical application of QSIs identified so far is still distant, likely due to their unsuitability for use in humans. A promising way to overcome this problem is searching for anti-QS side acti...
Phaseaoli pericarpium (bean pods) is a pharmacopeial plant material traditionally used as diuretic and antidiabetic agents. Diuretic activity of pod extracts was reported first in 1608. Since then Phaseoli tea figures many textbooks medicinal by patients. Despite the traditional use from Phaseolium vulgaris pericarp, limited information available on bioactivity, chemical composition, bioavailab...
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