Grifolin, a farnesyl phenolic compound isolated from the fresh fruiting bodies of the mushroom Albatrellus confluens, exhibits effective antitumor bioactivity in previous study of our group and other lab. In this study, we observed that grifolin inhibited tumor cells adhesion and migration. Moreover, grifolin reduced reactive oxygen species (ROS) production and caused cellular ATP depletion in ...

different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...

ft-sers (fourier transform surface enhanced raman scattering) of adriamycin and its complex with dna is reported. it is shown that in agreement with previous raman studies the interaction of adriamycin  with dna takes place through an intercalation mechanism. the presence of a new band at 731 cm-1 suggests that ring d of adriamycin is not involved in the intercalation process.

the aim of this work was to investigate the effect of silica coating on bioactivity and biodegradability of hydroxyapatite. in this purpose, we firstly attempted to synthesis hydroxyapatite (ha) nanoparticles and its silica coated (si-ha) sample in collagen matrix using calcium chloride, sodium phosphate and sodium silicate. characterization of the sample was carried out using fourier transform...

objective anti-rh d igg is used for the prevention of anti-d antibody production in rh- individuals who have been exposed to rh+ red blood cells. the stability of igg preparations as a solution is low, with a shelf life of a year or more. formulation of anti-rh d igg as a lyophilized preparation would decrease its degradation rate and increases its shelf life. the objective of this study was to...

BACKGROUND Doxorubicin is the preferred chemotherapeuticdrug for osteosarcoma treatment of which clinical efficacy is limited because of its chemo-resistance and cardiac toxicity. It is necessary to develop the combination regimen with complementary molecular mechanisms to reduce the side effects and enhance sensitivity of Doxorubicin. EGCG is a polyphenol in green tea with antitumor bioactivit...

bacillus thuringiensis strains were isolated from various soil samples collected from different regions of kahramanmaraş in turkey and were characterized by their colony morphology, pcr method with cryiab/ac, cryid, cry2 and cyt2 primers, and sds-page of crystal proteins with 130-140 and 60-70 kda molecular weights. plasmid profiles of selected isolates were also analyzed. among the cry genes s...

Objecttive (s): Silicate bioceramics like Baghdadite with chemical formula Ca3ZrSi2O9, has attracted the attention of researchers in biomedical field due to its remarkable in-vitro and in-vivo bioactivity and mechanical properties.Materials and Methods: Therefore, in the current study the baghdadite powder with Sol-Gel method was synthesized. Then, hydroxyapatite/Baghdadite (HA/Bagh) scaffolds ...

Diopside (DS) is a monoclinic pyroxene mineral with composition MgCaSi2O6. Lately,diopside (DS) has beenintroduced as a bioceramics due to its best bioactivity and biocompatibility. It has a good strength andtoughness than those of hydroxyapatite (HT). In this project, bioactivity of diopside (DS) powder wereevaluated and investigated. For synthesized of diopside (DS) powder, ...