نتایج جستجو برای: antiproliferative effect

تعداد نتایج: 1648039  

Journal: :The Journal of clinical endocrinology and metabolism 2009
Marina Montagnani Marelli Roberta M Moretti Stefania Mai Joanna Januszkiewicz-Caulier Marcella Motta Patrizia Limonta

BACKGROUND GnRH-II has been shown to exert a strong antiproliferative action on tumors of the female reproductive system. The data so far reported on the effects of GnRH-II on prostate cancer growth are controversial. Moreover, it is still unclear through which receptor [type I or type II GnRH-receptor (GnRH-R)] GnRH-II might modulate cancer cell proliferation. OBJECTIVE The objective of this...

Journal: :Cancer journal 2006
Victoria Gayosso Luis F Montano Rebeca López-Marure

Dehydroepiandrosterone, an adrenal hormone derived from cholesterol, can be metabolized to estrogens (estradiol) and androgens (testosterone). In this study, we evaluated whether the antiproliferative effect induced by dehydroepiandrosterone in MCF-7 cells (an estrogen-dependent breast cancer cell line) is direct, or indirect, through its conversion to estradiol or testosterone. Although dehydr...

Journal: :Biochemical pharmacology 2003
Christopher J Fowler Kent-Olov Jonsson Anna Andersson Juha Juntunen Tomi Järvinen Séverine Vandevoorde Didier M Lambert Jeffrey C Jerman Darren Smart

It has previously been shown that the endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG) inhibit the proliferation of C6 glioma cells in a manner that can be prevented by a combination of capsazepine (Caps) and cannabinoid (CB) receptor antagonists. It is not clear whether the effect of 2-AG is due to the compound itself, due to the rearrangement to form 1-arachidonoylglycerol (1-AG)...

Journal: :British Journal of Pharmaceutical Research 2013

Journal: :Nutrition and Food Science International Journal 2020

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