Background: Brucella species can cause infection in a wide range of animals and human beings. Oxidative events against brucella infection are not well elucidated. It is possible that brucellosis may be related to increased free radical production and antioxidant depletion. Thus, the aim of this study was to determine the total antioxidant capacity (TAC) before and after treatment of patients wi...

Physiological processes, as aerobic metabolism and inflammatory response, generate reactive oxygen species (ROS) that may induce cellular injury when their amount is increased and antioxidant defense mechanisms are overwhelmed. Also, ROS are generated following UV skin irradiation able to deplete the natural antioxidant defenses in the skin. The increase in exposure to UV may lead to photoaging...

Diabetic kidney disease (DKD) is the single most common cause of end stage renal disease (ESRD) with the annual costs of caring for patients with DKD exceeding more than $9 billion in the United States (Centers of Disease Control and Prevention, 2005). Every diabetic patient has up to a 40% lifetime risk to develop DKD, if the patient does not die prematurely of cardiovascular disease (CVD) (Pa...

Simvastatin-Niacin Therapy To the Editor: This article1 attracted our attention first because of the wide implications and second because of the related editorial comments2 that sort of urged the physicians to “stop prescribing antioxidant vitamins to prevent and treat heart disease.” In these studies, subjects with coronary artery disease were divided into 4 treatment groups, namely (1) placeb...

In view of the oxidative stress implicated in the pathophysiology of a wide variety of different diseases, a therapeutic strategy to elevate the antioxidant defenses of the body may be of assistance in protecting from different diseases and disorders. This special issue includes 19 articles that emphasize the importance of medicinal plants in augmenting oxidative stress in cancer, aging, inflam...

Simvastatin-Niacin Therapy To the Editor: This article1 attracted our attention first because of the wide implications and second because of the related editorial comments2 that sort of urged the physicians to “stop prescribing antioxidant vitamins to prevent and treat heart disease.” In these studies, subjects with coronary artery disease were divided into 4 treatment groups, namely (1) placeb...

INTRODUCTION Delayed posthypoxic leukoencephalopathy (DPHL) may result from a variety of hypoxic insults, including respiratory depression from an opiate overdose. The underlying pathophysiological mechanism of DPHL remains uncertain. We describe a patient with a typical case of DPHL who responded clinically to antioxidant treatment. METHODS Clinical, serological, and radiographic investigati...

The increased oxidative stress in critically ill patients could exert pathophysiological role in the pathogenesis of multiple organ failures, as suggested by recent clinical trials of antioxidant therapies. Prophylactic administration of antioxidant vitamins or glutamine, incorporated in the nutritional support or given as sepasituation and could be influenced by several current therapeutic int...

Ataxia telangiectasia (AT) is a rare genetic disorder characterized by immunodeficiency, early onset neurological degeneration, hypersensitivity to ionizing radiation and a high incidence of lymphoid cancers. The disease results from bi-allelic mutations in the AT mutated (ATM) gene involved in cell cycle checkpoint control and repair of DNA double-strand breaks. Evidence has been accumulating ...