Malignant tumors are potential killers of human life, seriously endangering people’s physical health. As far as the treatment malignant is concerned, there exist many therapeutic methods such surgery, radiotherapy, chemotherapy, among which chemotherapy an important means antitumor therapy. Chemotherapy antineoplastic agents can be divided into alkylating agents, metalloplatinum, plant drugs, a...

Despite the classification as known or suspected human carcinogens, by the International Agency for Research on Cancer, the antineoplastic drugs are extensively used in cancer treatment due to their specificity and efficacy. As human carcinogens, these drugs represent a serious threat to the healthcare workers involved in their preparation and administration. This work aims to contribute to bet...

Innovative Nano-carrier-based transdermal patches, a wonder of advanced technologies, have received overwhelming endorsement in medicinal applications primarily the provision anti-neoplastic drugs. The purpose this study was to review limitations conventional therapeutic initiatives namely chemotherapy, having several adverse effects, including significant inflammation, toxicity, and discomfort...

To clarify genotoxic effects of occupational exposure to antineoplastic drugs in Japan, we examined DNA damage, assessed by the comet assay, in 121 female nurses and 46 female clerks working at three hospitals in the northeast of Japan. The comet assay is considered to be a sensitive and rapid method for DNA strand break detection in individual cells, and tail length and tail moment are used as...

The effects of serine phosphorylation on the DNA cleavage/religation equilibrium of topoisomerase II and the sensitivity of the enzyme to antineoplastic drugs were characterized. Both casein kinase II and protein kinase C »ere used for these studies. Each kinase incorporated a maxi mum of ~ 1.4 phosphate molecules per homodimer of topoisomerase II. When the enzyme was incubated with both kinas...