Raphanus sativus L. belongs to family Brassicaceae and is more commonly known as Radish. Radish has long been grown as a food crop and are of high medicinal value. R. sativus seeds and leaves contain ‘raphanin’ which has been found to possess antibacterial and antifungal potential. In the present study, R. sativus root juice was evaluated for its antimicrobial potential against five bacterial s...

Microbial contamination is of critical importance when it comes to production processes, especially in the pharmaceutical industry. Avoidance of microbial contamination throughout production processes is therefore crucial. However, what are the essentials of an effective hygiene regime? And what kind of hygiene measures are to be taken in order to be safe and effective? This work demonstrates h...

The aim of this study was to optimise the antimicrobial efficacy of plant essential oils (EOs) for control of Listeria spp. and spoilage bacteria using food model media based on lettuce, meat and milk. The EOs evaluated were lemon balm, marjoram, oregano and thyme and their minimum inhibitory concentrations (MIC) were determined against Enterobacter spp., Listeria spp., Lactobacillus spp., and ...

Introduction Therapeutic Drug Monitoring (TDM) is an evolving tool used to optimise the administration of antimicrobial agents; which are well documented to have toxic side effects [1]. In combination with increasing antimicrobial resistance and emphasis on cost-efficiency, provision of the optimal dose of antimicrobial therapy is a very attractive prospect. Pharmacokinetic (PK) indices can be ...

BioIntraface®, Inc., located in Riverside, Rhode Island, was formed in February of 2009 to commercialize its biomaterials surface treatment technologies. The platform technologies involve the creation of economical, multifunctional metal oxide and polymer materials and coatings to control the bioactivity and antimicrobial properties of medical devices and implants. Biointraface® has continued o...

Rational use of antibiotic is the key approach to improve the antibiotic performance and tackling of the antimicrobial resistance. The efficacy of antimicrobials are influenced by many factors: (1) bacterial status (susceptibility and resistance, tolerance, persistence, biofilm) and inoculum size; (2) antimicrobial concentrations [mutant selection window (MSW) and sub-inhibitory concentration];...

Large amounts of antimicrobial agents are still being used in modern swine production in many countries around the world. This facilitates the emergence and development of antimicrobial resistance. Bacteria causing infections in swine have in several cases acquired resistance to a number of the agents most commonly used for treatment, making it difficult to predict the efficacy of different ant...

conclusions p. spinosa ethanol extract can be used as a mouthwash for treatment of the oral infections. more clinical and toxicological studies are required for providing its efficacy. results p. spinosa ethanol extract with higher-level phenolic and flavonoid contents showed the highest antioxidant and antimicrobial effects, in comparison with the other extracts. bacillus sp. and streptococcus...

A series of fatty acid ester and ether derivatives have been chemically synthesised based on carbohydrate and non-carbohydrate polyhydroxylated scaffolds. The synthesised compounds, along with their corresponding fatty acid monoglyceride antimicrobials, were evaluated for antimicrobial activity against Staphylococcus aureus and Escherichia coli. Of the derivatives synthesised, several of the ca...

OBJECTIVE To determine the efficacy of topical antimicrobials for acute otitis externa. STUDY DESIGN Systematic review and random effects meta-analysis of randomized, controlled trials with parallel groups permitting one or more of the following comparisons: antimicrobial vs placebo, antiseptic vs antimicrobial, quinolone antibiotic vs nonquinolone antibiotic, steroid-antimicrobial vs antimic...