The aim of the present study was to evaluate antihyperglycemic activity of methanol extract of Citrus maxima leaf (MECM) in streptozotocin (STZ; 65 mg/kg b.w.) induced diabetic rats. Three days after STZ induction, diabetic rats received MECM orally at a dose of 200 and 400 mg kg-1 body weight daily for 15 days. Glibenclamide (0.5 mg kg-1 p.o.) was used as a reference drug. Blood glucose levels...

Different doses of ethanolic extract of Stephania glabra tuber were evaluated for antihyperglycemic activity in alloxan induced diabetic mice. The oral administration of 100, 200 and 500 mg/kg body weight showed significant hypoglycemic activity. Glibenclamide (oral hypoglycemic agent, 25 mg/kg, p.o.) has been used as standard.

The natural product mangiferin (compound 7) has been identified as a potential glucokinase activator by structure-based virtual ligand screening. It was proved by enzyme activation experiment and cell-based assays in vitro, with potency in micromolar range. Meanwhile, this compound showed good antihyperglycemic activity in db/db mice without obvious side effects such as excessive hypoglycaemia.

Over the years, ethnopharmacological and phytochemical investigations have been conducted to understand potential effects of Croton genus on several diseases. It has revealed that these terpenoid-rich species traditionally used treat gastrointestinal diseases, heal wounds, relieve pain a wide range therapeutic effects; however, those diabetes, as well their action mechanisms, not reviewed so fa...

Prevalent and incident heart failure (HF) is increased in people with type 2 diabetes mellitus, with risk directly associated with the severity of hyperglycemia. Furthermore, in patients with type 2 diabetes mellitus, mortality is increased ≈10-fold in patients with versus without HF. Reducing HF with antihyperglycemic therapies, however, has been unsuccessful until recently. In fact, HF as an ...

BACKGROUND The purpose of this study was to determine the characteristics of adults with type 2 diabetes mellitus (T2DM) that correlate with greater risk of hypoglycemia and determine the impact of hypoglycemia on health-related quality of life, work productivity, and medication adherence from a patient perspective. METHODS Data from a large web-based survey were retrospectively analyzed. Adu...

Stevioside, a glycoside present in the leaves of the plant, Stevia rebaudiana Bertoni (SrB), has acute insulinotropic effects in vitro. Its potential antihyperglycemic and blood pressure-lowering effects were examined in a long-term study in the type 2 diabetic Goto-Kakizaki (GK) rat. Rats were fed 0.025 g x kg(-1) x d(-1) of stevioside (purity > 99.6%) for 6 weeks. An intra-arterial catheter w...