Presenting a case report of corneal graft infection by an opportunistic fungus, , which is reported to be resistant many antifungals. Antibiotic sensitivity the organism and management such infections has been discussed.

OBJECTIVES Candida albicans is the most prevalent fungal pathogen of humans, causing a wide range of infections from harmless superficial to severe systemic infections. Improvement of the antifungal arsenal is needed since existing antifungals can be associated with limited efficacy, toxicity and antifungal resistance. Here we aimed to identify compounds that act synergistically with echinocand...

Use of oral antifungals in the treatment of onychomycosis is commonplace; but their use can be limited by safety and patient concerns. Due to their broader safety margins, topical antifungals (efinaconazole, tavaborole, and ciclopirox) are a useful option in the treatment of mild-to-moderate onychomycosis in the USA, but their antifungal activity has yet to be directly compared. This study aims...

The syndromes of mineralocorticoid excess describe a heterogeneous group clinical manifestations leading to endocrine hypertension, typically either through direct activation receptors or indirectly by impaired pre-receptor enzymatic regulation disturbed renal sodium homeostasis. phenotypes these disorders can be caused inherited gene variants and somatic mutations may acquired upon exposures e...

Introduction The fungicidal properties of morpholines with large ring N-substituents was first reported in 1965 [ l ] and since then several (Fig. 1) have been marketed for the control of plant pathogenic fungi. Dodemorph, tridemorph, aldimorph and fenpropimorph are used to control powdery mildews and have both protective and eradicant properties. They are systemic in action, being absorbed thr...

Candidais an opportunistic pathogen that causes mucosal and deep systemic candidiasis. The emergence of drug resistance and the side effects of currently available antifungals have restricted their use as long-term prophylactic agents for candidal infections. Given this scenario, probiotics have been suggested as a useful alternative for the management of candidiasis. We analyzed the available ...

Imidazoles and triazoles represent major classes of antifungal azole derivatives. With respect to UDP-glucuronosyltransferase (UGT) enzymes, the drug metabolism focus has mainly concentrated on their inhibitory effects with little known about azoles as substrates for UGTs. N-Glucuronide metabolites of the imidazole antifungals, tioconazole and croconazole, have been reported, but there are curr...

AIMS The aim of this cohort study was to estimate the risk of clinical acute liver injury among users of oral antifungals identified in the general population of the General Practice Research Database in UK. METHODS The cohort included 69 830 patients, 20-79 years old, free of liver and systemic disease, who had received at least one prescription for either oral fluconazole, griseofulvin, itr...