Trobicin (Actinospectacin) is a new antibiotic obtained from Streptomyces spectabilis developed by the Research Laboratories of Messrs. Upjohn. It is prepared as a white powder, 1 4-1 6 g. of which is dissolved in distilled water. It has been stated to have a wide range of antibacterial activity and has already been shown (Willcox, 1962) to be effective in cases of acute gonorrhoea in males whe...

Vesicoureteral reflux (VUR) is diagnosed in ∼1% of children. The main goal of treatment is preservation of renal function by preventing recurrent urinary tract infection (UTI) refractory to antibiotic therapy. Surgical treatment options include endoscopic injection or ureteral reimplantation. Subureteral Teflon (polytetrafluoroethylene) injection (STING) is an endoscopic treatment option no lon...

The pharmacokinetics of thiamphenicol and its distribution in various body fluids were studied after repeated intramuscular injection in clinically healthy adult Moroccan crossed Sardi-D'Man sheep. Thiamphenicol was rapidly absorbed from injection sites yielding peak plasma concentrations within 15-30 min. The elimination from the blood was also rapid, with a biological half-life of 1.51 +/- 0....

Purpose. To determine the clinical features, microbial profiles, treatment outcomes, and prognostic factors for endogenous bacterial endophthalmitis (EBE). Methods. The medical records of 27 eyes of 21 patients diagnosed with EBE for 11 years were reviewed. Collected data included age, site of infection, visual acuities (VAs), microbial profiles, and treatment regimen. Results. The mean age was...

Since it has been established that the injection of plasmid DNA can lead to an efficient expression of a specific protein in vivo, nonviral gene therapy approaches have been considerably improved, allowing clinical trials. However, the use of antibiotic resistance genes as selection markers for plasmid production raises safety concerns which are often pointed out by the regulatory authorities. ...

We used 16S rRNA gene sequencing to examine the posteffects of antibiotic treatment on the structure and metabolism of rumen microbiota. Twelve goats were randomly assigned into two groups, with one group receiving intramuscular streptomycin injection at 40 mg/kg bodyweight daily for 10 days. At 4 weeks after treatment with antibiotic, three goats were randomly selected from each group and swit...

Fregnan, G. B. (University of Wisconsin, Madison) and D. W. Smith. Mycobactocidin, a new antiboitic active against mycobacteria. J. Bacteriol. 83:1069-1076. 1962.-A new antibiotic, produced by a strain of Staphylococcus epidermidis, is described. The name mycobactocidin is proposed because of the specificity of the antibiotic against mycobacteria. Methods for extraction and purification of the ...

Subconjunctival injection of 100 mg of aztreonam in rabbits with Pseudomonas aeruginosa endophthalmitis produced transiently high antibiotic concentrations in most intraocular sites. Concentrations of approximately 2.5 micrograms/ml were achieved in the vitreous humor 15 min after injection and persisted for 6 h. Repeated intramuscular injections in dosages of 25 mg/kg every 4 h resulted in dru...