Human tuberculosis remains a huge global public health problem with an estimated 1/3rd of the population being infected. Defensins are antibacterial cationic peptides produced by a number of cell types, most notably neutrophil granulocytes and epithelial cells. All three defensin types (α-, β-, and θ-defensins) have antibacterial activities, mainly through bacterial membrane permeabilization. D...

BACKGROUND Antibacterial resistant infections are rising continuously, resulting in increased morbidity and mortality worldwide. With no new antibiotic classes entering the market and the possibility of returning to the pre-antibiotic era, the Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) was established to address this problem. We aimed to quantify the scale and scope of pu...

The introduction of new antibiotic compounds into therapy initiates the development of resistance by the target bacteria. Resistance increases the risk of treatment failure with potentially serious consequences. Local application of antibacterial compounds to the eyes may lead to bacterial resistance in bacterial isolates from the eyes. The incidence of resistant strains of common pathogens is ...

UNLABELLED The emerging epidemic of drug resistance places the development of efficacious and safe antibiotics in the spotlight of current research. Here, we report the design of next-generation aminoglycosides. Discovery efforts were driven by rational synthesis focusing on 4' alkylations of the aminoglycoside paromomycin, with the goal to alleviate the most severe and disabling side effect of...

The Pharmacists Role in Antimicrobial Resistance Antimicrobial resistance (AMR) poses a significant threat to the wellbeing of society. The issue comes at a time when there is a limited number of new antibacterial agents being developed, the use of antibiotics in livestock is being questioned and greater awareness is placed on the value of immunization in mitigating the spread of infectious dis...

Several plants have been evaluated not only for alone antimicrobial activity, but as resistance-modifying agent. This work is the first on the modulation of antibiotic activity by Lantana camara L. extracts against multiresistant strains of Escherichia coli and Staphylococcus aureus. The antibacterial activities of leaf and root ethanol extracts alone or in association with aminoglycosides were...

Aqueous as well as organic extracts of eight herbs were screened for their antibacterial effects against Staphylococcus (S) aureus, Escherichia (E) coli, Candida (C) albicans and Saccharomyces (S) cerevicae. C. sativum was found effective antibacterial, excepting the C. albicans. A. barbadensis expressed growth inhibition zones against E. coli, S. cerevicae, and C. albicans. Antibacterial activ...

Quinolone has the disadvantage of easily acquired drug resistance. It is important to prescribe it wisely for a high eradication rate. The current study aimed to determine the clinical and bacteriological factors for optimal levofloxacin-containing triple therapies in second-line H. pylori eradication. We enrolled a total of 158 H. pylori-infected patients who failed H. pylori eradication using...

introduction: vaginitis is an inflammatory and infectious disease in human host that involved vaginal mucosa. increase of resistance to various antibacterial agent has been very significant in three or four recent decades and this important subject reveals the use of new and natural sources such as plants with medical and antimicrobial property for eradication of these infections. therefore, th...