Pathogen virulence is usually thought to evolve in reciprocal selection with the host. While this might be true for obligate pathogens, the life histories of opportunistic pathogens typically alternate between within-host and outside-host environments during the infection-transmission cycle. As a result, opportunistic pathogens are likely to experience conflicting selection pressures across dif...

The pathogen virulence is traditionally thought to co-evolve as a result of reciprocal selection with its host organism. In natural communities, pathogens and hosts are typically embedded within a web of interactions with other species, which could affect indirectly the pathogen virulence and host immunity through trade-offs. Here we show that selection by predation can affect both pathogen vir...

An auxotrophic mutant of nontyphoidal Salmonella (NTS) strain (Salmonella Oslo) was phenotypically characterized in this study. The characterization based on phenotype, morphology, motility, biofilm forming ability, growth kinetics, etc. phenotypic results from the above experiments determined that showed variation characters wild-type strain. Subsequently, and NTS were subjected to epithelial ...

Professor of Biology University of Texas at San Antonio Candidiasis Drug Discovery and Development: New Approaches Targeting Virulence for Discovering and Identifying New Antifungal Drugs Targeting pathogenetic mechanisms rather than essential processes represents a very attractive alternative for the development of new antibiotics. This may be particularly important in the case of antimycotics...

background: escherichia coli is the most causative agent of urinary tract infections (utis). apart from all human infectious diseases, uti have a high prevalence and in most cases, escherichia coli is a dominance bacterium which can cause pyelonephritis and cystitis. the aim of the study was to determine the occurrence of some virulence genes expressing fimbriae, production of hemolysin and aer...