The monocyte/macrophage-derived cytokine, Tumor Necrosis Factor Alpha (TNF-α) plays a central role in effective granulomatous immunity to Mycobacterium tuberculosis infections in humans. The present study was conducted to document changes in the serum TNF-α level of patients after varying durations of anti-tuberculous therapy as compared to normal healthy controls. A comparative study was condu...

OBJECTIVES To compare the clinical and laboratory features of tuberculous meningitis with bacterial meningitis and to determine if protein glucose ratio in the cerebrospinal fluid can be predictive of the condition. METHODS It was a retrospective descriptive study at the Paediatric Ward of Aga Khan University Hospital, Karachi, for which records of 46 patients with tuberculous meningitis and ...

The emergence of drug-resistant Tuberculosis has become a global health problem. Herbal drugs promise other potential options for treatment. This study aimed to investigate the anti-mycobacterial activity three plants: Piper longum, Cressa cretica and Calotropis gigantea. methanolic extract these plants was tested against Mycobacterium tuberculosis H37Rv using BACTEC MGIT-960 Automated system, ...

We report a 38-year-old Chinese woman with lupus nephritis on peritoneal dialysis and long-term maintenance steroid therapy. This patient developed paradoxical deterioration during anti-tubercular therapy for tuberculous lymphadenitis. The deterioration resolved spontaneously without change to pharmacotherapy. Paradoxical deterioration that may spontaneously resolve is a potential complication ...

•Routine 2-week liver tests were evaluated in a 1247 patient cohort treated for TB. •Anti-tuberculous therapy (ATT) led to drug-induced injury (DILI) 8.3%. •Risk of late TB-DILI increased 2.2-fold every 30 U/L rise pre-treatment ALT. 2.1-fold gradient ALT change. Objective Tuberculosis Drug Induced Liver Injury (TB-DILI) is common and potentially severe complication associated with anti-tubercu...

purpose : to report a patient with orbital tuberculosis (tb) without any history of systemic involvement case report : a 41-year-old afghani man who presented with progressive painless swelling in lateral side of the left upper eyelid and diplopia. he did not have history of fever or pulmonary disease. histopathology revealed a granulomatous inflammation with caseation necrosis. microbiological...

BACKGROUND/AIMS This study aimed to evaluate the efficacy of computed tomography (CT)-guided bone biopsy for the diagnosis of spinal infection and compared the clinical outcomes between tuberculous and pyogenic spinal infections. METHODS The retrospective cohort study included patients who received CT-guided bone biopsy at a tertiary hospital over the 13 years. RESULTS Among 100 patients, 6...

The clinical features, investigations, treatment and outcome were studied in 104 patients with definite or probable tuberculous meningitis. The diagnosis of definite tuberculous meningitis required the growth of Mycobacterium tuberculosis from cultures, or a positive polymerase chain reaction (PCR) assay for M. tuberculosis. In probable tuberculous meningitis, cultures and the PCR assay were ne...