Deregulated melanogenesis is involved in melanomagenesis and melanoma progression and resistance to therapy. Vitamin D analogs have anti-melanoma activity. While the hypercalcaemic effect of the active form of Vitamin D (1,25(OH)2D3) limits its therapeutic use, novel Vitamin D analogs with a modified side chain demonstrate low calcaemic activity. We therefore examined the effect of secosteroida...

The presence of true neurons in the rodent pineal gland is still a matter of controversy. In this work, by using immunohistochemistry with five antibodies against calcium-binding proteins (calbindin-D28k, calretinin, calmodulin, neurocalcin and S-100 beta) and Cricetomys gambianus, a rodent belonging to Muridae family living in Africa, we were able to illustrate the presence of neurons in the p...

This article highlights a neglected feature of Joseph Lister's work, namely how, in addition to promoting germ theories and the principles of the antiseptic system, he also devoted much time and effort to communicating the performative aspects of antisepsis and of the many other surgical innovations that he developed. Attention to 'detail' and striving for 'improvement' were crucial to Listeria...

W h i l e l i t t l e information is a v a i l a b l e on the d i s t r i b u t i o n and incidence of most of the diseases with rodent reservoirs, many of them are known to be widespread and may have considerable p u b l i c health importance in some of the foci in which they are found. The World Health Organization is carrying out investigations on the epidemiology of several diseases with ro...

Given that rodents are responsible for nearly 280 million cases of undernutrition worldwide and about 400 people affected by rodent-associated zoonoses annually, management rodent populations agricultural pests and/or reservoirs pathogens is a major food security public health matter. In sub-Saharan Africa, the median crop loss due to 16% in field around 8% during storage. The impact on not wel...

Increased awareness of spatiotemporal variation in species interactions has motivated the study of temporally-resolved food web dynamics at the landscape level. Empiricists have focused attention on cross-habitat flows of materials, nutrients, and prey, largely ignoring the movement of predators between habitats that differ in productivity (and how predators integrate pulses in resource availab...

background: resistance to most antimalarial drugs has encouraged the development of novel drugs. an alternative source for discovering such drugs is natural products. some ferulago species are used in folk medicine for their sedative, tonic and anti-parasitic effects. besides, coumarins isolated from this genus found to have in vitro anti-leishmanicidal effect. the present study is aimed to eva...

Topical administration of drugs is required for the treatment parasitic diseases and insect infestations; therefore, fabrication nanoscale drug carriers effective insecticide topical delivery needed. Here we report enhanced immobilization halloysite tubule nanoclay onto semiaquatic capybaras which have hydrophobic hair surfaces as compared to their close relatives, land-dwelling guinea pigs, ot...

Hypoxic-ischemic encephalopathy (HIE) remains to be a major cause of morbidity, mortality and severe neurodevelopmental disability in term neonates. Moderate whole body hypothermia is an established, effective neuroprotective therapy reduce long-term associated with HIE, however, research for adjunct therapies still warranted complement the effect hypothermia. In last decade, molecular hydrogen...

Anti-predator behaviour affects prey population dynamics, mediates cascading effects in food webs and influences the likelihood of rapid extinctions. Predator manipulations in natural settings provide a rare opportunity to understand how prey anti-predator behaviour is affected by large-scale changes in predators. Here, we couple a long-term, island-wide manipulation of an important rodent pred...