Hairy cell leukemia (HCL) is caused by the proliferation and accumulation of morphologically characteristic cells whose cell line of origin (lymphocyte versus monocyte) has not been determined. In an attempt to determine the cell line from which these cells are derived. we studied the cells from the peripheral blood and spleens of 6 patients with HCL for their cytochemical. immunologic, surface...

Abstract Para-Bombay is a rare phenotype with homozygous nonfunctional FUT1 gene and normal FUT2 leading to H-deficient red blood cells (RBCs) or without ABH substances, depending on inheritance of the ABO gene. This case about 5-day-old male baby suffering from sepsis who required 45-mL packed RBC transfusion. The baby’s sample tested as A 1 B, D+ mother’s group O, 4 discrepancy due isoaggluti...

Sera taken from AKR/J mice 7 d after the intravenous injection of 2,4,6-trinitrophenyl-lys-Ficoll (TNP-F) caused a specific inhibition of anti- trinitrophenol (TNP) plaque-forming cells (PFC) in vitro. This inhibition was reversed by the incorporation of 10(-8)-10(-7) M 2,4,6-trinitrophenyl- epsilon-amino-n-caproic acid (TNP-EACA) into the agar during the PFC assay. The factor responsible for t...

The induction by anti-immunoglobulin of patch and cap formation on mouse lymphocytes was inhibited by the addition of concanavalin A. This effect was reversed by alpha-methyl-D-mannoside, a competitive inhibitor of the binding of concanavalin A. Concanavalin A prevented both patch and cap formation, in contrast to the metabolic inhibitor NaN(3), which prevented only cap formation. This suggests...

Immune thrombocytopenia (ITP) is an acquired bleeding autoimmune disorder characterized by a markedly decreased blood platelet count. The disorder is variable, frequently having an acute onset of limited duration in children and a more chronic course in adults. A number of therapeutic agents have demonstrated efficacy in increasing the platelet counts in both children and adults. Anti-RhD immun...

BACKGROUND AND OBJECTIVES A targeted routine antenatal anti-D prophylaxis programme was implemented in Denmark where anti-D immunoglobulin is given based on the result from noninvasive antenatal screening for fetal RHD. Our objective was to evaluate compliance with this new programme right after its initiation. MATERIALS AND METHODS We examined the treatment outcome of 239 D-negative pregnant...