This review concerns the synthesis and biological activities of pyrazino[1,2-a]indoles pyrazino[1,2-a]indol-1-ones reported since 1997 discovery activity pyrazinoindole derivatives. In first part, we presented synthetic routes that have been from a methodological point view to access unit according cyclization reactions using or not metal catalysts. Then, syntheses neuropsychiatric, auto-immune...

the methanolic extract of whole plants of solanum nigrum l. was investigated for anti-inflammatory activity on the experimental animal models. the methanolic extract at a concentration of 100 mg.kg-1 and 200 mg.kg-1, p.o. showed the significant dose dependent anti-inflammatory activity in carrageenin and egg white induced hind paw oedema in rats. anti-inflammatory activity of the tested extract...

cancer is not just one disease, but a large group of almost one hundred diseases. its two main characteristics are uncontrolled growth of the cells in the human body and the ability of these cells to migrate from the original site and spread to distant sites. if the spread is not controlled, cancer can result in death. there has been continuous progress in the development of therapy for cancer....

Objective: Anti-cancer drug research plays an important role for chemotherapeutic treatments in various types of cancer. Pyrolidine derived compounds have been reported by many researchers to be a potent anti-cancer compound. It is aimed investigate the effects pyrolidine-derived that are thought new candidates with antiproliferative activity on DLD-1 and CCD-18CO cell lines. Material Methods: ...

This article refers to:RETRACTED ARTICLE: Structural characterization and anti-liver cancer activity of a Cu(II)-based coordination polymer

ferula persica, is the well-known species of the genus ferula in iran and has two varieties: persica and latisecta. they have both been extensively used in traditional medicine for a wide range of ailments. a great number of chemical compounds including sesquiterpene coumarins and polysulfides have been isolated from this plant. fresh plant materials, crude extracts and isolated components of f...

Marine collagen peptides (MCPs) are natural products prepared by hydrolyzing marine protein through a variety of chemical methods or enzymes. MCPs have range structures and biological activities widely present in species. also small molecular weight, easily modified, absorbed the body. These properties attracted great interest from researchers studying antioxidant, anti-tumor, anti-aging activi...

Valproic acid is widely used as an anti-epileptic globally. Anti-epileptic action is mediated by Gamma Amino Butyric Acid (GABA) receptors. In past and recently, several other clinical outcomes have been proposed by various studies. These under-reported clinical actions apart from anti-epileptic activity are mediated by various intracellular and extracellular pathways. Several mechanisms like H...

ABSTRACT The activity of flavonoids as anti-cancer compounds has attracted the attention researchers. Flavonoids are natural found in various plants and have been identified potential candidates for drugs. multiple mechanisms action, including inhibiting cancer cell growth, inducing apoptosis, formation new blood vessels. also possess antioxidant properties that protect normal cells from oxidat...

methanolic extract of solanum trilobatum linn. (mest) belonging to the family of solanacea was evaluated by hot plate and acetic acid induced writhing methods to assess its analgesic activity. the extract was also evaluated for its anti-inflammatory activity by subjecting into carrageenan, and cotton pellet induced granuloma tests for its effect on acute and chronic phase inflammation models in...