nalogue development is an intensively pursued goal. e rationale behind this is the selection of agents with cn "^proved therapeutic index with respect to the parent ^Pound but with an enhanced spectrum of activity, reduced toxicity. Sj P'^ubicin is a new anthracycline antibiotic, syntheed in an effort to find a cytotoxic agent with a better Cjr0raPeutic index than that of Adriamycin the parent ...

An actinomycete, isolated from a soil sample from Ontario, Canada, was studied taxonomically and named Actinosporangium bohemicum sp. nov. strain C-36,145. This strain was found to produce a complex mixture of e-pyrromycinone glycosides having antitumor properties. Marcellomycin, a member of this complex, was selected for further study. Conditions for production of this antibiotic were develope...

The risk of cardiotoxicity is the most serious drawback to the clinical usefulness of anthracycline antineoplastic antibiotics, which include doxorubicin (adriamycin), daunorubicin or epirubicin. Nevertheless, these compounds remain among the most widely used anticancer drugs. The molecular pathogenesis of anthracycline cardiotoxicity remains highly controversial, although the oxidative stress-...

PURPOSE The goal of this registry was to collect patient characteristics and safety data from patients from the Asia-Pacific region with early breast cancer receiving adjuvant chemotherapy containing docetaxel (Taxotere®). METHODS This registry was open-label, international, longitudinal, multicenter, and observational in design and included a prospective group of consecutive early breast can...

OBJECTIVE To investigate the new onset of mitral regurgitation in patients with otherwise normal echocardiograms after anthracycline treatment and to assess its relation to other selected indicators of myocardial damage. DESIGN Prospective echocardiographic and electrocardiographic study. SETTING Tertiary paediatric cardiac referral centre. PATIENTS 305 patients, aged 2-33 years (median 1...

The clinical efficacy of anthracyclines (e.g., doxorubicin and daunorubicin) in cancer therapy is limited by their severe cardiotoxicity, the etiology of which is still not fully understood. The development of anthracycline-induced cardiomyopathy has been found to correlate with myocardial formation and accumulation of anthracycline secondary alcohol metabolites (e.g., doxorubicinol and daunoru...

Chemotherapy with anthracyclines is associated with cardiotoxicity. Besides known risk factors such as cumulative dose and mediastinal irradiation, there are indications that genetic variation might also be associated with the development of anthracycline induced cardiotoxicity. In the current study a retrospective case control analysis was performed in oncology patients having received anthrac...

We evaluated the predictive value of a tumor's HER-2 status for chemotherapy response in the neoadjuvant setting and the effect of anthracycline dose intensity on this predictive value. HER-2 status was evaluated by immunochemistry on microbiopsy before neoadjuvant chemotherapy (monoclonal antibody CB-11; Novocastra) in 39 patients (group A) treated with FEC50 (500 mg/m(2) 5-fluorouracil, 50 mg...

The Cover Feature illustrates ion transfer and adsorption processes of anthracycline antibiotics affected by the dendritic polymer at liquid|liquid interfaces. More information can be found in Research Article T. Takami et al.

Background: Subacute cardiotoxicity, consisting of acute myocyte damage and associated left ventricular dysfunction, occurs early during anthracycline therapy. We investigated the impact of myocardial dysfunction, defined herein by a shortening fraction (SF) < 29 % at any time during or after anthracycline therapy, on late onset cardiomyopathy and all-cause mortality, among childhood cancer sur...