Cystic echinococcosis (CE) is a worldwide parasitic zoonosis caused by the larval stage of Echinococcus granulosus. Current chemotherapy against this disease is based on the administration of benzimidazoles (BZMs). However, BZM treatment has a low cure rate and causes several side effects. Therefore, new treatment options are needed. The antidiabetic drug glibenclamide (Glb) is a second-generat...

Although the concept of targeted or community-wide treatment for soil-transmitted helminths (STHs) is not new, having been initiated originally by the Rockefeller Sanitary Commission in the United States [1,2] and more recently supported by Warren [3] and others some 30 years ago as a feasible approach, it is only in the last 10 years, since the World Health Assembly resolution [4], that helmin...

Sixty plant species were collected in the Ivory Coast on the basis of an ethnobotanical literature using the following three criteria: activity against worms, diarrhoea and/or abdominal pain. Eighty six plant extracts were prepared using 90% ethanol and tested for potential anthelminthic activities with a larvicidal test of Haemonchus contortus. 25.6% of the extracts showed a high activity, 12....

Strongyloides stercoralis hyperinfection syndrome due to the acceleration of the autoinfective cycle of the nematode is a life-threatening form of the infection occurring in immunocompromised hosts. Intestinal ileus, which is commonly encountered in this form, may reduce the bioavailability and thus the efficacy of oral anthelminthic drugs used in the treatment of the S. stercoralis hyperinfect...