background and objective : due to the evolution of multidrug-resistant strains, screening of natural resources, especially actinomycetes, for new therapeutic agents discovery has become the interests of researchers. in this study, molecular, chemical and biological screening of soil actinomycetes was carried out in order to search for peptide-producing actinomycetes. materials and methods : 60 ...

Survival of pathogens in soil and water.................................... 232 Symbiosis and antibiosis ........................... 235 Antagonistic effects of bacteria..................................... 241 Spore-forming bacteria..................................... 243 Non-spore-forming bacteria..................................... 245 Actinomycetes..................................... 249...

Alloreactive T cells form an important barrier for organ transplantation. To reduce the risk of rejection patients are given immunosuppressive drugs, which increase the chance of infection and the incidence of malignancies. It has been shown that a large proportion of alloreactive T cells specifically recognize peptides present in the groove of the allogeneic MHC molecule. This implies that it ...

In our model system, we generated T cell clones specific for the HLA-DR4 (DRB1*0405)-index peptide (YWALEAAAD) complex. Based on response patterns of the T cell clones, analogue peptides containing single amino acid substitutions of the index peptide were classified into three types, agonists, antagonists or null peptides (non-agonistic and non-antagonistic peptides). Subtle structural changes ...

Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of targets. As such, cone snail peptides represent an interesting treasure for drug development. Here, we report five novel peptides isolated from the v...

Trichoderma virens (synonym, Gliocladium virens), a deuteromycete fungus, suppresses soilborne plant diseases caused by a number of fungi and is used as a biocontrol agent. Several traits that may contribute to the antagonistic interactions of T. virens with disease-causing fungi involve the production of peptide metabolites (e.g., the antibiotic gliotoxin and siderophores used for iron acquisi...

Abstract Blocking the binding of PD-1/PD-L1 has become an effective strategy in inhibition tumor immune escape. At present, it mainly depends on employment macromolecular antibodies, which target protein through one PD-1 or PD-L1 domains. In this study, we present a different strategy, aptamer modified molecularly imprinted polymer layer (APD–PD-L1–MIPL), to break for The APD–PD-L1–MIPL is prep...

the present investigation was carried out to isolate and characterize antagonistic bacteria against wilt causing fungal pathogen i.e. fusarium oxysporum, from the rhizosphere of tomato. fifty-six bacterial strains were isolated from the rhizosphere soil samples of healthy tomato fields, collected from different locations of faridabad district, haryana, india. out of these, ten isolates were fou...

Members of the genus Bacillus produced a diverse group antimicrobial compounds. Here, we presented antifungal activity and genome sequence analysis sp. 2211, potential plant-growth-promoting bacterium. Bacterial supernatants from strain 2211 cultures in nutrient broth (NB) potato dextrose (PDB) suppressed mycelial growth Pyricularia oryzae, Colletotrichum aenigma, fructicola Fusarium oxysporum....