1,2 dimethylhydrazine (DMH) rat model has been proven to be a valuable animal model of colorectal cancer. Because of its morphological similarity to human colorectal cancer, DMH rat model was used to produce information in histology and biochemistry of tumours development as well as on factors that retard or enhance tumorigenesis. Nevertheless, it has been shown that DMH model has limitations, ...

Bovine genital campylobacteriosis (BGC), caused by Campylobacter fetus subsp. venerealis, is associated with production losses in cattle worldwide. This study aimed to develop a reliable BGC guinea pig model to facilitate future studies of pathogenicity, abortion mechanisms and vaccine efficacy. Seven groups of five pregnant guinea pigs (1 control per group) were inoculated with one of three st...

Animal models for cancer therapy are invaluable for preclinical testing of potential cancer treatments; however, therapies tested in such models often fail to translate into clinical settings. Therefore, a better preclinical model for cancer treatment testing is needed. Here we demonstrate that an immunodeficient line of pigs can host and support the growth of xenografted human tumors and has t...

In recent years, Pulsed Field Ablation (PFA) has emerged as a novel non thermal energy source for ablation. To compare lesion durability and collateral damage between unipolar/biphasic PFA RF delivered through contact-force sensing catheter both in point-by-point fashion. A 4 arm pre-clinical study (n=12 swine) was designed with the multimodality generator TRUPULSE™ 2. nominal dose (12 pulses) ...

The claustrum seems to have been waiting for the science of connectomics. Due to its tiny size, the structure has remained remarkably difficult to study until modern technological and mathematical advancements like graph theory, connectomics, diffusion tensor imaging, HARDI, and excitotoxic lesioning. That does not mean, however, that early methods allowed researchers to assess micro-connectomi...

Golgi impregnation is unique in its ability to display the dendritic trees and axons of large numbers of individual neurons by histology. Here we apply magnetic resonance microscopy to visualize the neuroanatomy of animal models by combining histologic fixation chemistry with paramagnetic contrast agents. Although there is some differential uptake of the standard small-molecular-weight contrast...

Three-dimensional optical coherence tomography (3D-OCT) was used to image the structure and pathology of skeletal muscle tissue from the treadmill-exercised mdx mouse model of human Duchenne muscular dystrophy. Optical coherence tomography (OCT) images of excised muscle samples were compared with co-registered hematoxylin and eosin-stained and Evans blue dye fluorescence histology. We show, for...

The case of a 2.5-year-old sheep sent for diagnostic evaluation is presented. At the necropsy, mucoid degeneration coronary fat, pleural adhesions, hypostatic congestion, hemoperitoneum, reticulum, rumen, omasum, and abomasum distention were found. most significant finding was whitish, hard-to-touch appearance right atrium. atrial sample decalcified sectioning histopathology study. histology se...