Background & Aims: It is more important to know which of physical activities could be the most effective way to cause angiogenesis. In this regards, we have investigated an 8-week aerobic training on vascular endothelial growth factor (VEGF) and Endostatin (ES) in sedentary women. Materials & Methods: 20 volunteer inactive women were chosen and were randomly divided in 2 groups of aerob...

Inhibition of matrix-metalloproteinases (MMPs) by tissue inhibitors of metalloproteinases (TIMPs) has been shown in vivo to decrease metastasis and tumor-associated angiogenesis. Our laboratory is interested in understanding the role of these proteins at the pericellular microenvironment of tumor and endothelial cells. Secretion of MMPs by tumor cells enables the migration, invasion and metasta...

The expression of the placental growth factor (PGF) in cancer cells and tumor microenvironment can contribute to induction angiogenesis, supporting cell metabolism by ensuring an adequate blood supply. Angiogenesis is a key component as it facilitates delivery nutrients oxygen rapidly growing cells. PGF recognized novel target for anti-cancer treatment due its ability overcome resistance existi...

The formation of new blood (angiogenesis) and lymphatic (lymphangiogenesis) vessels are major events associated with most epithelial malignancies, including breast cancer. Angiogenesis is essential for cancer cell survival. Lymphangiogenesis critical in maintaining tumoral interstitial fluid balance importing tumor-facilitatory immune cells. Both vascular routes also serve as conduits metastasi...

Snake venom, as a natural biotoxin, is widely present in nature and can act coordination with variety of signal regulatory proteins, playing significant role the regulation tumor cell proliferation, metastasis, invasion, angiogenesis. Malignant tumors have long attracted attention medical community leading cause death humans. In this paper, we focus on reviewing progress snake venom apoptosis, ...

Background: It has been shown that about 80% of deaths in diabetic patients are due to cardiovascular disorders, which called Diabetic Heart Disease or DHD, the most important dysfunction and vascular damage, consequently stopping coronary angiogenesis. Despite many advances made field medical research long-standing clinical history diabetes mellitus, risk disease associated with not reduced. M...

background and objectives: angiogenesis is essential for growth and metastasis of solid malignancies. tumor vessel count and expression of vascular endothelial growth factor (vegf), a potent angiogenic factor, have been associated with prognosis. this study was designed to assess vessels density by using cd31 and cd105 (endoglin) and their correlation with expression of vegf and proliferative i...

objective(s):although previous studies have confirmed the beneficial effects of human umbilical cord matrix stem cell (hucm) transplantation post myocardial infarction (mi), but this stem cell resource has no potential to induce angiogenesis. in order to achieve the process of angiogenesis and cardiomyocyte regeneration, two required factors for cardiac repair agents were examined namely; hucm ...

exosomes, as a mediator of cell-to-cell transfer of genetic information, act an important role in intercommunication between tumor cells and their niche including fibroblasts, endothelial cells, adipocytes and monocytes. several studies have shown that tumor cells can influence their neighboring cells by releasing exosomes. these exosomes provide signaling cues for stimulation, activation, prol...

Objective(s) We investigated the effects of low-dose morphine on nitric oxide (NO) and angiogenesis in two-kidney one clip hypertensive (2K1C) rats. Materials and Methods Male rats were divided into two groups: sham-clip operated and 2K1C. Each group subdivided into saline and morphine (3 mg/kg i.p. 8 weeks) groups. Blood pressure, heart rate, plasma renin activity (PRA), NO concentration an...