Computergestiitzte Verfahren fur toxikologische Tests werden mittlerweile verstarkt als Alternative zu Tierversuchen gesehen. Diese Konferenz gab Einblick in den aktuellen Stand dieser Verfahren zur Voraussage der Toxizitat chemischer Substanzen. Im Zentrum der Forschung stehen hierbei QSAR-Methoden (quantitative structure-activity relationships), bei denen statistische Beziehungen zwischen der...

Three hundred and seven lepromatous and borderline lepromatous patients in five participating centres (Freetown, Karachi , Bombay, Madras, Chetput) were randomized to receive one of the three following drug regimens : A, DDS 1 00 mg/ day; B, DDS 1 00 mg/day + Rifa 600 mg/day; and C, Rifa 600 mg/day + Isopro­ dian (PTH 1 75 mg, INH 1 75 mg, dapsone 50 mg) , 2 tablets/day. An adjustment was made ...

Isoneochamaejasmin A (INCA), a biflavonoid, is one of main active ingredients in the dried root of Stellera chamaejasme L., a widely used traditional Chinese medicine. In the present study, we identified the glucuronidation metabolite of INCA and characterized the UDP glucuronosyltransferases (UGTs) responsible for INCA glucuronidation. 7-O-glucuronide (M1) and 4'-O-glucuronide (M2) were identi...

1 Vermerk Inhalte dieser Masterarbeit wurden am 13. März 2013 im Fachjournal " Biology Letters " unter dem Namen " Goffin cockatoos wait for qualitative and quantitative gains but prefer´better´ tómore´ " Isabelle B. Laumer hat die Datenaufnahme der Studie durchgeführt und war maßgeblich bei der Erstellung der schriftlichen Form der Veröffentlichung beteiligt. Teile dieser Publikation wurden in...

sehr schnelle und kurzfristige Änderungen des C02-Gaswechsels bei Pflanzen quantitativ erfaßt werden. 5. Der URAS kann für Assimilationsund Atmungsmessungen sowohl an Landpflanzen als auch an submersen Wasserpflanzen verwendet werden. Seine hohe Empfindlichkeit gestattet es, diese Stoffwechselvorgänge auch an geringen Versuchsmaterialmengen zu untersuchen. 6. Die Temperatur des" Raumes, in welc...

The application of the ‘direct amide cyclization’ conditions to the linear delta-hydroxy diamide 11 is described (Scheme 3). Instead of the cyclization to the expected nine-membered cyclodepsipeptide, only the chloro acid 12 was obtained. Its formation could be explained by consecutive formation of the 1,3-oxazol-5(4H)-one 16 and the six-membered imino lactone 17 as intermediates (Scheme 4). Th...

Allelopathic substances can be used to develop weed control alternatives based on natural products. The objective of this study was to compare the phytotoxic activity of aqueous leaf extracts of Rapanea umbellata with the toxicity of a synthetic herbicide on the germination and growth of weed species. The weeds species barnyard grass (Echinochloa crus-galli), wild poinsettia (Euphorbia heteroph...

In 2001 the metaphor of ‘crossing the Rubicon’ and many variations on this theme ran through the German debate about research using human embryonic stem cells. This article studies how the Rubicon metaphor was argumentatively exploited after having been prominently used by President Rau in a speech Wird alles gut? – Für einen Fortschritt nach menschlichem Maß (Will everything turn out well? For...

Background: Research is an important motivating factor for pursuing a career in academic medicine, but the relation between motivation and factors involved in scientific research are not clear. Purpose: To explore the motivational orientation for doing research and its relation with the attitudes towards science and publication practice among the faculty at a medical school. Methods: We used a ...

This research tested the mechanisms by which a narrative entertainment televisionprogram influences safe sex intentions. Drawing on existing research and theorizing onnarrative persuasion and overcoming resistance, this study examined the process throughwhich entertainment programs generate persuasive influence. 367 undergraduates viewedeither a dramatic narrative program or...