In ancient Mesopotamia, a triple helix water screw, invented to raise water from one level to another, was the basis of a hydraulic system of agricultural innovation that irrigated ordinary farms as well as the Hanging Gardens of Babylon, one of the seven wonders of the ancient world. i The triple helix as a physical innovation is superseded by the triple helix of social innovation. On one leve...

The hereditary bone disorder osteogenesis imperfecta is often caused by missense mutations in type I collagen that change one Gly residue to a larger residue and that break the typical (Gly-Xaa-Yaa)(n) sequence pattern. Site-directed mutagenesis in a recombinant bacterial collagen system was used to explore the effects of the Gly mutation position and of the identity of the residue replacing Gl...

The folding and assembly of procollagen occurs within the cell through a series of discrete steps leading to the formation of a stable trimer consisting of three distinct domains: the N-propeptide, the C-propeptide and the collagen triple helix flanked at either end by short telopeptides. We have established a semi-permeabilized cell system which allows us to study the initial stages in the fol...

Purpose This article aims to discuss adaptation of innovation network during crisis, using the context an Indian state’s response early stages COVID-19 pandemic. Design/methodology/approach The is based on a combination data from public sources and interviews with entrepreneurs innovators state obtained period January–May 2020. Findings A hybrid approach low barriers between triple helix agents...

abstract it has been proposed that we think of continuing medical education (cme) as a two-stranded helix, in which one strand represents the internal characteristics of the learner-physician, the other strand the culture and environment in which he or she practices and lives. in many countries, the product of these two strands has been increasingly termed ‘continuing professional development’,...

This article uses the cases of the development of internet in Zambia and of genomics in Brazil to highlight the important role of units in the Triple Helix (TH) model. These are the "linker units" that mobilize university, government and industry/partner resources to create and incubate businesses. It argues that these units break down traditional boundaries to create a more porous community, w...