CONTEXT Tumor induced osteomalacia related to anaplastic thyroid cancer has never been reported. OBJECTIVE We describe a case of tumor induced osteomalacia (TIO) in a patient with a fibroblast growth factor 23 (FGF-23) secreting anaplastic thyroid carcinoma. The current imaging modalities are reviewed. DESIGN AND INTERVENTION Clinical, biochemical, and radiological assessments were done, in...

Angiosarcoma of the thyroid has long been a controversial entity, and it is histologically defined as cleft-like anastosmosing spaces lined by large, atypical cells of endothelial lineage. However, clear-cut separation between the angiosarcoma and anaplastic carcinoma of the thyroid is difficult because they yield nearly the same clinical prognosis and overlapping histologic findings. We report...

Anaplastic (undifferentiated) thyroid carcinoma is one of the most aggressive malignancies known to humans. It carries an almost uniformly fatal prognosis and, despite accounting for only 1.6% of thyroid malignancies in the United States, is responsible for more than half of all deaths attributed to thyroid cancer (1–3). Worldwide, anaplastic carcinoma constitutes 1–7% of all thyroid cancer cas...

Thyroid malignant neoplasm develops from follicular or parafollicular thyroid cells. A higher proportion of anaplastic thyroid cancer has an adverse prognosis. New drugs are being used in clinical treatment. However, for advanced thyroid malignant neoplasm such as anaplastic thyroid carcinoma, the major impediment to successful control of the disease is the absence of effective therapies. Oncol...

PURPOSE Anaplastic thyroid carcinoma is rare, yet lethal despite aggressive therapy. Molecular targeting may be beneficial using the rexinoid LGD1069, a retinoid X receptor-selective agonist, as a novel treatment. In this report, we describe the efficacy of LGD1069 in anaplastic thyroid carcinoma in vitro and assess the in vivo treatment effects on a responsive cancer. Additionally, we explore ...

Anaplastic thyroid carcinoma is a significantly fatal endocrine neoplasm, with an average survival time of 4-12 months following diagnosis. The present study reports the case of a 57-year-old male patient who presented to the Bağcılar Training and Research Hospital (Istanbul, Turkey) due to swelling in the neck and difficulty swallowing. The jugular mass biopsy results were consistent with a di...

UNLABELLED Thyroid cancer is the most common endocrine cancer, accounting for about 1% of all cancers. Sarcomas, lymphomas and metastases to the thyroid gland are rare and only with a handful of descriptions in the literature. OBJECTIVE To describe rare histological types of thyroid cancer found in a reference center. METHODS Medical chart review from admitted patients diagnosed with thyroi...

nloaded plastic thyroid carcinomas are deadly tumors that are highly invasive, particularly into the bones. gh oncogenic Ras can transform thyroid cells into a severely malignant phenotype, thyroid carcinoo not usually harbor ras gene mutations. Therefore, it is not known whether chronically active Ras butes to thyroid carcinoma cell proliferation, although galectin-3 (Gal-3), which is strongly...

Paraneoplastic leukocytosis was defined as elevated white blood cell (WBC) levels caused by cytokines, likely produced by the tumor itself, without evidence of infection or myeloproliferative disease. We report a case of anaplastic thyroid carcinoma with leukocytosis caused by elevated production of granulocyte colony-stimulating factor (G-CSF) by the carcinoma. Initially, acute pyelonephritis ...

Anaplastic thyroid carcinoma (ATC) represents about 1% of all thyroid carcinomas [1]. ATC is the most aggressive form of thyroid carcinoma especially when metastatic accounting for 14-50% of all thyroid cancer related deaths [2]. Prognosis and outcomes following local progression or metastasis are poor using conventional therapies such as surgery, chemotherapy, and external beam radiation thera...