This paper considers inventory models with advance demand information and flexible delivery. Customers place their orders in advance, and delivery is flexible in the sense that early shipment is allowed. Specifically, an order placed at time t by a customer with demand leadtime T should be fulfilled by period t+T ; failure to fulfill it within the time window [t, t+T ] is penalized. We consider...

abstract background and objective: highly active antiretroviral therapy (haart) can effectively prevent the progression of hiv-1 replication and increase life expectancy. there are numerous causes of treatment failure and the leading one is drug resistance. thus, we aimed to determine the hiv rt gene drug resistance mutations in patients treated with antiretroviral medications. material and met...

This paper presents an improvement of the Bandwidth Inheritance Protocol (BWI), the natural extension of the well-known Priority Inheritance Protocol (PIP) to resource reservation schedulers. The modified protocol allows for a better management of nested critical section, removes unneeded overheads in the management of task block and unblock events, and introduces a run-time deadlock detection ...

OBJECTIVE To determine whether short-time, real-time continuous glucose monitoring (RT-CGM) has long-term salutary glycemic effects in patients with type 2 diabetes who are not on prandial insulin. RESEARCH DESIGN AND METHODS This was a randomized controlled trial of 100 adults with type 2 diabetes who were not on prandial insulin. This study compared the effects of 12 weeks of intermittent R...

Recently, we developed a series of cytotoxic peptide conjugates containing 14-O-glutaryl esters of doxorubicin (DOX) or 2-pyrrolino-DOX (AN-201). Serum carboxylesterase enzymes (CE) can partially hydrolyze these conjugates in the circulation, releasing the cytotoxic radical, before the targeting is complete. CE activity in serum of nude mice is about 10 times higher than in human serum. Thus, w...

the objective of the current study was to evaluate the reproducibility of a reverse transcriptase pcr (rt-pcr)-based technique to differentiate viable and dead salmonella cells in raw and sterilized milk. the microorganism was initially inoculated into the milk samples followed by incubating at 37°c for 4 h prior to inactivation by heat at 80°c for 10 min. the treated and non-treated samples we...

Gen ekspresyonunun post-transkripsiyonel düzenleyicisi olarak bilinen miRNA’lar ökaryotik canlılarda çeşitli fizyolojik ve patolojik süreçlerde rol oynamaktadır. miRNA'ların rollerinin ortaya konulması ile birlikte üzerine yapılan çalışmaların sayısı da gün geçtikçe artmaktadır. Yapılan çalışmalar bütün hücre doku tiplerinde eksprese olduğu konmuştur. miRNA ekspresyon profilinin konması için yö...