Recently, we developed a series of cytotoxic peptide conjugates containing 14-O-glutaryl esters of doxorubicin (DOX) or 2-pyrrolino-DOX (AN-201). Serum carboxylesterase enzymes (CE) can partially hydrolyze these conjugates in the circulation, releasing the cytotoxic radical, before the targeting is complete. CE activity in serum of nude mice is about 10 times higher than in human serum. Thus, w...

After a selection of bright children from the schools of the district in which the University is located had been made by the Social Service Department of the Laboratory of Psychology, the children reported to the Psychological Clinic for physical and mental tests and measurements. The weight, height, head and body dimensions were taken at this time, and certain other data were secured, such as...

A growing body of research suggests that personality characteristics relate to physical health; however, this relation ship has primarily been tested in cross-sectional studies that have not followed the participants into old age. The present study utilizes data from a 70-year longitudinal study to prospectively examine the relationship between the adaptive defense mechanisms in midlife and obj...

Farm assurance schemes are an inevitable and essential part of the UK livestock industries as they provide valuable assurances to the market over food safety, nonhuman animal welfare, and environmental concerns. However, there is potential for welfare assessment within such schemes to extend beyond existing resource-based parameters to include outcome-based observations of the behavior and phys...

We improved the approximation of the model of the wormhole generated physical universe constructed by Choudhury and Pendharkar. We show here that the negative pressure of the unphysical wormhole can generate the right physical condition to explain the correct sign of the deacceleration parameter q0. The negative sign of q0 implies an accelerating universe.

Mobile technology has become increasingly common in today’s everyday life. However, mobile payment is surprisingly not among the frequently used mobile services, although technologically advanced solutions exist. Apparently, there is still a lack of acceptance of mobile payment services among consumers. The conceptual model developed and tested in this research thus focuses on factors determini...

The present study examined the moderating role of social support and challenging behaviour on the stress-physical health relationship in parents caring for children with intellectual disabilities. Parents of children with intellectual disabilities (n = 70) reported more physical health problems compared to control parents (n = 45) and were more likely to visit their general practitioner. Furthe...

This study investigated the economics of multisystemic therapy (MST) versus individual therapy (IT) using rearrest data from a 13.7-year follow-up (Schaeffer & Borduin, 2005) of a randomized clinical trial with serious juvenile offenders (Borduin et al., 1995). Two types of benefits of MST were evaluated: The value to taxpayers was derived from measures of criminal justice system expenses (e.g....

This article examined the long-term effects of multisystemic therapy (MST) vs. individual therapy (IT) on the prevention of criminal behavior and violent offending among 176 juvenile offenders at high risk for committing additional serious crimes. Results from multiagent, multimethod assessment batteries conducted before and after treatment showed that MST was more effective than IT in improvin...

How can collective action evolve when individuals benefit from cooperation regardless of whether they pay its participation costs? According to one influential perspective, collective action problems are common, especially when groups are large, but may be solved when individuals who have more to gain from the collective good or can produce it at low costs provide it to others as a byproduct. S...