cations for understanding the pathogenesis of (and potentially developing more effective targeted therapy for) this high-risk group of AMLs. It is also clear that the concept of a role for aberrant DNA methylation and the components of the epigenetic machinery in the pathogenesis of AML continues to gain momentum, and we can expect to see more examples of these relationships emerging in the nea...

This paper proposes a new adaptive importance sampling (AIS) technique for approximate evaluation of multidimensional integrals. Whereas known AIS algorithms try to find a sampling density that is approximately proportional to the integrand, our algorithm aims directly at the minimization of the variance of the sample average estimate. Our algorithm uses piecewise constant sampling densities, w...

Clinical observations with AN-1792 using tissue amyloid plaque immunoreactivity (TAPIR) analyses established for the first time evidence in humans that antibodies against beta-amyloid-related epitopes are capable of slowing progression in Alzheimer's disease. Antibodies derived upon TAPIR assay selection may specifically target the pathologic neoepitopes of aggregated A beta species present in ...

In this document, we define the NADA security architecture based on refined use case scenarios, a derived high level model and security analysis. For the architecure design and verification we are applying the well known STRIDE model.

Spinning dust appears to be the best explanation for the anomalous emission that has been observed at ∼ 10 − 60 GHz. One of the best examples of spinning dust comes from a HII region in the Perseus molecular cloud. Observations of other HII regions also show tentative evidence for excess emission at frequencies ∼ 30 GHz, although at lower emissivity levels. A new detection of excess emission at...

In this paper, we introduce the concept of 3-D radar signatures in a slow time-range-Doppler, fast timerange-Doppler and frequency-range-Doppler. Then, we describe how to utilize 3-D time or frequency-rangeDoppler signatures to extract information for detecting, relocating and re-focusing moving targets. Finally, we use AN/APY-6 X-band radar data for the demonstration of ground moving target de...

In a multi-study naturalistic quasi-experiment involving 269 students in a semester-long introductory philosophy course, we investigated the effect of teaching argument diagramming (AD) on students’ scores on argument analysis tasks. An argument diagram is a visual representation of the content and structure of an argument. In each study, all of the students completed preand posttests containin...