Neurodegenerative disease is one of the problems faced by postmenopausal women due to estrogen deficiency. Phytoestrogen compounds can be used as an alternative treatment for diseases caused deficiency binding their receptors through receptor (ER) dependent pathway. With in silico studies, this study aims predict how phytoestrogen will stop neurons from dying using ER Genistein, daidzein, glyci...

the patients often seek medical care. Ascending pathways in the spinal cord that relay nociceptive information from the periphery to supraspinal central nervous system sites has been studied as potential targets for disrupting pain processing and providing relief. Despite the considerable advances in knowledge regarding the basic mechanisms underlying visceral pain and visceral hyperalgesia, no...

In this report, the extracts from fruit and leaves of Couroupita guianensis were isolated using chromatographic methods investigated for chemical composition. Four triterpenoid compounds identified as betulinic acid, oleanolic β-amyrin friedelin. Their structures interpreted based on modern spectra such MS, NMR compared with previously published spectral data.

A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced guinea-pigs' platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by measuring 1D and 2D NMR, two of them are the triterpenes β...

the aerial parts of salvia glutinosa afforded in addition to lupeol, a - and ? - amyrin a furanosesquiterpene, its structure being established by high field nmr techniques. the relative configuration at c-1, c-10, c-4, c-5 and c-6 of 6?tigloyloxyglechomafuran 1 was determined by the observed noe's

Miconia is one of the largest genus of the Melastomataceae, with approximately 1,000 species. Studies aiming to describe the diverse biological activities of the Miconia species have shown promising results, such as analgesic, antimicrobial and trypanocidal properties. M. albicans leaves were dried, powdered and extracted to afford chloroformic and methanolic extracts. Total phenolic contents i...