Antimicrobial peptides (AMPs) are nowadays understood as broad multifunctional tools of the innate immune system to fight microbial infections. In addition to its direct antimicrobial action, AMPs can modulate the host immune response by promoting or restraining the recruitment of cells and chemicals to the infection focus. Binding of AMPs to lipopolysaccharide is a critical step for both their...

BACKGROUND Antimicrobial peptides (AMPs) have the potential to serve as an alternative to antibiotic. AMPs usually exert bactericidal activity via direct killing of microbial pathogens. Reports have proposed that by harnessing innate immune activation, AMPs can regulate pathogen invasion and may control infection. It has been reported that AMPs could be utilized to activate the innate mucosal i...

Bacterial resistance to conventional antibiotics is currently a real problem all over the world, making novel antimicrobial compounds a real research priority. Some of the most promising compounds found to date are antimicrobial peptides (AMPs). The benefits of these drugs include their broad spectrum of activity that affects several microbial processes, making the emergence of resistance less ...

In an era of discrete tube or transistor op-amp modules, any potential advantage to be gained from fully-differential circuitry was masked by primitive op-amp module performance. Fullydifferential output op-amps were abandoned in favor of single ended op-amps. Fully-differential op-amps were all but forgotten, even when IC technology was developed. The main reason appears to be the simplicity o...

Autonomous mobile programs (AMPs) have been proposed for load management in dynamic networks. An AMP is aware of its resource needs and periodically seeks a better location in the network to reduce execution time. AMPs have previously been measured using mobile Java Voyager on local area networks (LANs). We have constructed a simulation model of AMPs and reproduced 4 sets of experiments on homo...

Black tiger shrimp Penaeus monodon is one of the major shrimp species being cultured in Asian countries. Disease outbreaks have resulted in a decline of P. monodon cultivation and severe losses in the shrimp production. To combat harmful microorganisms, shrimp produce diverse classes of antimicrobial peptides (AMPs) as part of their immune defense. In P. monodon, several cDNA sequences of AMPs ...

Antimicrobial peptides (AMPs) are part of the armament that insects have developed to fight off pathogens. Insect AMPs are typically cationic and often made of less than 100 amino acid residues. Although their structures are diverse, most of the AMPs can be assigned to a limited number of families. The most common structures are represented by peptides assuming a alpha-helical conformation in o...

Antimicrobial peptides (AMPs) are ancient and conserved across the tree of life. Their efficacy over evolutionary time has been largely attributed to their mechanisms of killing. Yet, the understanding of their pharmacodynamics both in vivo and in vitro is very limited. This is, however, crucial for applications of AMPs as drugs and also informs the understanding of the action of AMPs in natura...

Although simple and low-cost interventions for sickle cell disease (SCD) exist in many developing countries, child mortality associated with SCD remains high, in part, because of the lack of access to diagnostic tests for SCD. A density-based test using aqueous multiphase systems (SCD-AMPS) is a candidate for a low-cost, point-of-care diagnostic for SCD. In this paper, the field evaluation of S...

Sinorhizobium meliloti differentiates into persisting, nitrogen-fixing bacteroids within root nodules of the legume Medicago truncatula. Nodule-specific cysteine-rich antimicrobial peptides (NCR AMPs) and the bacterial BacA protein are essential for bacteroid development. However, the bacterial factors central to the NCR AMP response and the in planta role of BacA are unknown. We investigated t...