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Vellas B, Coley N, Ousset PJ, et al; GuidAge Study Group. Long-term use of standardised ginkgo biloba extract for the prevention of Alzheimers disease (GuidAge): a randomised placebo-controlled trial. Question In elderly patients who report memory complaints to their primary care physicians, does ginkgo biloba extract reduce risk for Alzheimer disease (AD)? Methods Design: Randomized placebo-co...

Neurodegenerative diseases are frequently associated with structural changes in the brain. Magnetic Resonance Imaging (MRI) scans can show these variations and therefore be used as a supportive feature for a number of neurodegenerative diseases. The hippocampus has been known to be a biomarker for Alzheimers disease and other neurological and psychiatric diseases. However, it requires accurate,...

Background Apolipoprotein B (APOB) is well-known for its role in cholesterol metabolism. We recently showed that APOB protein levels are elevated the CSF of patients suffering from sporadic Alzheimer’s disease (AD) compared to control individuals (Picard et al, Alzheimers Dement. https://doi.org/10.1002/alz.12442). Since rare coding variants were discovered association with early-onset familial...

To classify each stage for a progressing disease such as Alzheimers disease is a key issue for the disease prevention and treatment. In this study, we derived structural brain networks from diffusion-weighted MRI using whole-brain tractography since there is growing interest in relating connectivity measures to clinical, cognitive, and genetic data. Relatively little work has used machine learn...