Amiodarone is used in treatment of cardiac arrhythmias. Therapeutic use of amiodarone is limited by its side effects, including pulmonary toxicity. Human Placenta Extract (HPE) contains a variety of bio-active substances. Thus, the present study aimed to quantitatively evaluate the protective effects of HPE on the structural lung changes induced by amiodarone using stereological methods. Spragu...

Our objective was to test the effect of inhibition of thromboxane synthase versus inhibition of cyclooxygenase (COX)-1/2 on pulmonary gas exchange and heart function during simulated pulmonary embolism (PE) in the rat. PE was induced in rats via intrajugular injection of polystyrene microspheres (25 micro m). Rats were randomized to one of three posttreatments: 1) placebo (saline), 2) thromboxa...

BACKGROUND AND AIMS To investigate whether performing alveolar recruitment or adding inspiratory pauses could promote physiologic benefits (VT) during moderately-high-frequency positive pressure ventilation (MHFPPV) delivered by a conventional ventilator in a porcine model of severe acute respiratory distress syndrome (ARDS). METHODS Prospective experimental laboratory study with eight pigs. ...

Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) affect 4.5–7.1% of the patients admitted to the intensive care unit with acute respiratory failure.1,2 In our population, we found that ARDS affects 15.3 per 100,000 persons per year.3 Although the reported mortality of patients with ALI and ARDS has improved, it remains high among the causes of death in the intensive ca...

Knowledge of the dead space breathing volume is important in order to insure that mechanical ventilation is sufficient and to standardize experimental conditions. Measurement of the dead space at various time points within an experimental protocol provides useful information in elucidating the meaning and possibly the cause of other physiologic changes. Therefore, a system has been developed to...

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objective: martynia annua l. (m. annua), (martyniaccae) has been traditionally used in the treatment of epilepsy, sore throat and inflammatory disorders. the leaf paste is used topically on tuberculosis of the lymphatic glands and wounds of domestic animals. tephrosia purpurea (t. purpurea), (fabaceae) has been used traditionally as a remedy for asthma, gonorrhea, rheumatism and ulcers. this st...