LEMURS (INFRAORDER: Lemuriformes) are a radiation of strepsirrhine primates endemic to the island of Madagascar. As of 2012, 101 lemur species, divided among five families, have been described. Genetic and morphological evidence indicates all species are descended from a common ancestor that arrived in Madagascar ∼55-60 million years ago (mya). Phylogenetic relationships in this species-rich in...

Alu elements make up the largest family of human mobile elements, numbering 1.1 million copies and comprising 11% of the human genome. As a consequence of evolution and genetic drift, Alu elements of various sequence divergence exist throughout the human genome. Alu/Alu recombination has been shown to cause approximately 0.5% of new human genetic diseases and contribute to extensive genomic str...

Abstract The se del allele is one of the nonsecretor alleles ( ) FUT2 generated by an Alu-mediated recombination event and was first found in Indian Bombay phenotype individuals who have anti-H, anti-A, anti-B antibodies their serum. As well as antibodies, anti-H clinically significant because it causes sever hemolytic transfusion reactions. Like , 302 having a missense single nucleotide polymo...

In this study, the relationship between IL-1β [-31 C / T] gene polymorphisms in herniated lumbar disc is offered to be investigated. was amplified by PCR [Polymerase Chain Reaction] method. Polymorphic site cut with restriction enzyme Alu I and genotyping were performed. Fifteen subjects (15%) homozygous for C/C allele at -31 position of gene. Of remaining 85 subjects, 64 (64%) heterozygous C/T...

BACKGROUND Variation in epigenetic modifications, arising from either environmental exposures or internal physiological changes, can influence gene expression and may ultimately contribute to complex diseases such as asthma and allergies. We examined the association of asthma and allergic phenotypes with DNA methylation levels of retrotransposon-derived elements. METHODS We used data from 704...

OBJECTIVES Although antiretroviral therapy (ART) effectively suppresses HIV-1 replication, it does not eradicate the virus and ART interruption consistently results in rebound of viraemia, demonstrating the persistence of a long-lived viral reservoir. Several approaches aimed at reducing virus persistence are being developed, and accurate measurements of the latent reservoir (LR) are necessary ...

Non-invasive blood-based molecule markers are evaluated as promising biomarkers these days. Here we investigated the potential of cell-free circulating DNA Integrity (cfDI) as blood-based marker for the prediction of recurrence during the follow-up of breast cancer patients within a prospective study cohort. cfDI was determined in plasma of 212 individuals, by measuring ALU and LINE1 repetitive...

OBJECTIVES To investigate the association between methylation of transposable elements Alu and long-interspersed nuclear elements (LINE-1) and lung function. DESIGN Cohort study. SETTING Outpatient Veterans Administration facilities in greater Boston, Massachusetts, USA. PARTICIPANTS Individuals from the Veterans Administration Normative Aging Study, a longitudinal study of aging in men, ...

Whole genome amplification (WGA) permits genotyping DNA samples of limited quantity, expanding the number of samples available for genetic epidemiology studies. WGA, however, produces various nucleic acid side products that may interfere with accurate DNA quantification and further analysis. Although quality control of whole genome amplified DNA (wgaDNA) before genotyping is essential to preven...