Individuals susceptible to high-altitude pulmonary oedema (HAPE) are characterised by an abnormal increase of pulmonary artery systolic pressure (PASP) in hypoxia and during normoxic exercise, reduced hypoxic ventilatory response, and smaller lung volume. In 37 mountaineers with well-documented altitude tolerance, it was investigated whether any combination of these noninvasive measurements, in...

RADIOGRAPHIC evidence of right ventricular enlargement with bulging of the main pulmonary artery13 and electroveetoreardiographic signs of right ventricular preponderance2' 4-6 are common findings in people born and living at high altitudes. Anatomically, the existence of right ventricular hypertrophy has been demonstrated both in adults7-9 and children.10 Recently, hemodynamic studies have dis...

conclusions the etiology of pah in thalassemia is multifactorial such as inflammatory mediators. also, the absence of the spleen plays an important role in developing a high trv and pah. results average age of the patients was 21.15 ± 6.68 years. no significant difference was observed in the pap between the 2 groups of thalassemia major and intermedia and also the 2 sex groups. indeed, 6.6% of ...

To determine the separate and interactive effects of fetal inflammation and neonatal hyperoxia on the developing lung, we hypothesized that: 1) antenatal endotoxin (ETX) causes sustained abnormalities of infant lung structure; and 2) postnatal hyperoxia augments the adverse effects of antenatal ETX on infant lung growth. Escherichia coli ETX or saline (SA) was injected into amniotic sacs in pre...

This review focuses on the effects of altitude exposure from 1 to several days or weeks as occurs in tourists, trekkers, and mountaineers who visit high altitude and normally reside near sea level. We briefly review the acute physiological adjustments and early acclimatization that occur in the cardiovascular system and the lungs of healthy individuals. These ensure life-sustaining oxygen deliv...

High-altitude pulmonary hypertension (HAPH) affects individuals residing at altitudes of 2,500 meters and higher. Numerous pathogenic variables play a role in disease inception and progression and include low oxygen concentration in inspired air, vasculopathy, and metabolic abnormalities. Since HAPH affects only some people living at high altitude genetic factors play a significant role in its ...

RADIOGRAPHIC evidence of right ventricular enlargement with bulging of the main pulmonary artery13 and electroveetoreardiographic signs of right ventricular preponderance2' 4-6 are common findings in people born and living at high altitudes. Anatomically, the existence of right ventricular hypertrophy has been demonstrated both in adults7-9 and children.10 Recently, hemodynamic studies have dis...

Medicine at high altitude provides important insights into the acute and chronic effects of hypoxia. Acute mountain sickness (AMS) is a common syndrome occurring after acute ascent to over 2,500 m and is caused by increased capillary permeability. A number of factors have been identified that increase the risk of AMS, in particular exercise. Avoiding rapid ascent, undue exercise and the use of ...

a2-year-old cachectic cross-breed gelding was admitted toveterinary teaching hospital of university of tehran followingthe onset of a marked respiratory distress, coughing and ventraledema. clinical examinations indicated harsh respiratory andexpiratory sounds as well as jugular vein distention. therespiratory and heart rates were 35/min and 60 bpm, respectively.agrade iii/iv pansystolic murmur...

BACKGROUND It is not known whether the mild hypoxia experienced by passengers during commercial air travel triggers hypoxic pulmonary vasoconstriction and increases pulmonary artery pressure in flight. Insidious pulmonary hypertensive responses could endanger susceptible passengers who have cardiopulmonary disease or increased hypoxic pulmonary vascular sensitivity. Understanding these effects ...