Supernumerary chromosomes (B chromosomes) occur in approximately 15% of eukaryote species. Although these chromosomes have been extensively studied, knowledge concerning their specific molecular composition is lacking in most cases. The accumulation of repetitive DNAs is one remarkable characteristic of B chromosomes, and the occurrence of distinct types of multigene families, satellite DNAs an...

Segmental duplications and other highly repetitive regions of genomes contribute significantly to cells' regulatory programs. Advancements in next generation sequencing enabled genome-wide profiling of protein-DNA interactions by chromatin immunoprecipitation followed by high throughput sequencing (ChIP-seq). However, interactions in highly repetitive regions of genomes have proven difficult to...

A family I.3 lipase from Pseudomonas sp. MIS38 (PML) contains 12 repeats of a nine-residue sequence motif in the C-terminal region. To elucidate the role of these repetitive sequences, mutant proteins PML5, PML4, PML1, and PML0, in which 7, 8, 11, and all 12 of the repetitive sequences are deleted, and PMLdelta19, in which 19 C-terminal residues are truncated, were constructed. Escherichia coli...

Although stroke affects nearly 15 million people worldwide annually, with 5 million experiencing some degree of permanent paralysis, appropriate rehabilitation programs can improve motor function and quality of life. For example, repetitive voluntary movement of the paralyzed limb can improve function and remodel neural circuits. Robotic technologies may be effective for stroke rehabilitation b...

Introduction. Osteochondritis dissecans (OCD) of the capitellum is a localized disorder of the subchondral bone, in a region with limited healing capacity. Although its aetiology is still unknown, it has been associated with repetitive microtrauma. The natural history of this disease involves the evolution for degenerative joint disease in approximately half of the patients, with early identifi...

ACUPUNCTURE IN MEDICINE 2001;19(1):46-49. www.medical-acupuncture.co.uk/aimintro.htm Summary A case of repetitive epileptic fits in a post stroke patient after transcutaneous electrical nerve stimulation (TENS) is presented. It seems more likely than not that the TENS triggered the repetitive fits in this patient. Although the risk of this adverse effect seems to be small, it should be borne in...

As is the case with mammals in general, primate genomes are inundated with repetitive sequence. Although much of this repetitive content consists of "molecular fossils" inherited from early mammalian ancestors, a significant portion of this material comprises active mobile element lineages. Despite indications that these elements played a major role in shaping the architecture of the genome, th...

Spondylolysis and spondylolisthesis are common diagnoses made in the athlete suffering from persistent back pain. Although the etiology of this continuum of conditions is uncertain, genetic predisposition and repetitive trauma have been strongly implicated. Sports in which participants are subjected to repetitive hyperextension across the lumbar spine pose a risk for such injuries. Football lin...