OBJECTIVES The essential oil of Melaleuca alternifolia (tea tree oil) and its components have antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria, fungi and viruses. The mechanism(s) by which Pseudomonas aeruginosa NCTC 10662 maintains a decreased susceptibility to tea tree oil and components was investigated. RESULTS Ethylene diamine tetraacetic acid enhan...

The antitumor activity of the tea tree oil (TTO) derived product, Melaleuca Alternifolia Concentrate (MAC) was characterized mechanistically at molecular and cellular level. MAC analyzed for its anticancer against human prostate (LNCaP) breast (MCF-7) cancer cell lines growing in vitro. (0.02–0.06% v/v) dose-dependently induced intrinsic (mitochondrial) apoptotic pathway both LNCaP MCF-7 lines,...

BACKGROUND Finding an effective treatment for acne that is well tolerated by the patients is a challenge. One study has suggested the efficacy of tea tree oil in treatment of the acne vulgaris. AIM To determine the efficacy of tea tree oil in mild to moderate acne vulgaris. METHODS This was a randomized double-blind clinical trial performed in 60 patients with mild to moderate acne vulgaris...

Tea tree oil (TTO) merupakan minyak esensial yang berasal dari Melaleuca alternifolia mengandung terpinen-4-ol. TTO memiliki aktivitas sebagai antimikroba. gel bersifat hidrofobik sehingga membutuhkan sistem penghantaran untuk bisa berpenetrasi melewati stratum korneum. Tujuan penelitian ini adalah membuat nanoemulgel TTO, menggunakan Carbopol 940 dan Tween 80 digunakan surfaktan. Optimasi form...

The evolution of microorganisms resistant to many medicines has become a major challenge for the scientific community around the world. Motivated by the gravity of such a situation, the World Health Organization released a report in 2014 with the aim of providing updated information on this critical scenario. Among the most worrying microorganisms, species from the genus Candida have exhibited ...

The ability of remote sensing applications to accurately differentiate priority vegetation types was evaluated on a 664-hectare habitat management unit on Agassiz National Wildlife Refuge, located in Marshall County in northwest Minnesota. The Refuge is a diverse complex of wetland and upland habitats, largely inaccessible by foot. Its relative inaccessibility, coupled with the known occurrence...

The combination of a 4% tea tree oil nasal ointment and 5% tea tree oil body wash was compared with a standard 2% mupirocin nasal ointment and triclosan body wash for the eradication of methicillin-resistant Staphylococcus aureus carriage. The tea tree oil combination appeared to perform better than the standard combination, although the difference was not statistically significant due to the s...