Frovatriptan, a 5-HT1B and 5-HT1D receptor agonist, is used for the treatment of acute migraine attack. This molecule is classified into second line therapy because of its slow onset of action (peak response obtained after 4 hours of administration) and low bioavailability (25%). Moreover, its therapy is the most costly among all triptans. Attempt has been made in present work to suggest a way ...

A debate rages over imposing liability on manufacturers or users of insecure systems. Imposing either liability or fines on the creators or users of insecure systems may work, but how are buyers to distinguish? We propose a variety of signals and analyze them. We evaluate when signals may be preferable to liability as a mechanism for enhancing security.

Case Description A 20 kg 5-year-old boy was rushed by his parents to our adult trauma unit. They reported a history of a persistent grand mal seizure that had begun a half-hour earlier. Attempts at intravenous cannulation by the staff were unsuccessful. An anesthesiologist who happened to be examining another patient suggested the use of intranasally administered droplets of midazolam. Within 2...

Routine intravenous blood transfusion is difficult when the blood pressure falls significantly or veins are inaccessible or are sclerotic due to multiple transfusions. Here, we describe the use of penile corpora cavernosa (CC), as an alternative route for blood transfusion and fluid replacement. The study was conducted in 15 men, 7 with massive burns, 6 with sclerotic veins from repeated inject...

On the other hand, path choice is a very complex context to be simulated because of the above mentioned large number of alternative paths and of their overlapping which, within the random utility (RU) theory, means correlations among utilities. This complexity suggests the use of demanding models (like the Probit model) without a closed form which require simulation methods, thus inducing high ...

The European Palliative Care Research Collaboration is updating the EAPC recommendations on opioids in cancer pain management. A systematic literature search on Medline on the use of alternative routes for opioid application identified 242 papers, with 72 publications included in the final evaluation. Two or more alternative routes of opioid application were compared in 18 papers with a total o...

Charge and spin density waves, periodic modulations of the electron, and magnetization densities, respectively, are among the most abundant and nontrivial low-temperature ordered phases in condensed matter. The ordering direction is widely believed to result from the Fermi surface topology. However, several recent studies indicate that this common view needs to be supplemented. Here, we show ho...

In particular configurations, the BGP scaling mechanisms defined in "BGP Route Reflection An Alternative to Full Mesh IBGP" and "Autonomous System Confederations for BGP" will introduce persistent BGP route oscillation. This document discusses the two types of persistent route oscillation that have been identified, describes when these conditions will occur, and provides some network design gui...

Every human likes choices. But today’s fast route planning algorithms usually compute just a single route between source and target. There are beginnings to compute alternative routes, but this topic has not been studied thoroughly. Often, the aspect of meaningful alternative routes is neglected from a human point of view. We fill in this gap by suggesting mathematical definitions for such rout...