The Hippo pathway regulates growth through the transcriptional coactivator Yorkie, but how Yorkie promotes transcription remains poorly understood. We address this by characterizing Yorkie's association with chromatin and by identifying nuclear partners that effect transcriptional activation. Coimmunoprecipitation and mass spectrometry identify GAGA factor (GAF), the Brahma complex, and the Med...

The purpose of the work. To evaluate effectiveness use probiotic Alflorex and mesalazine in complex therapy patients with irritable bowel syndrome (IBS) diarrhea constipation, combined obesity, CT TT genotypes according to polymorphic variant C-159T CD14 gene. Materials methods. We examined 48 IBS associated obesity. In dynamics treatment we determined content serum C-reactive protein (CRP), tu...

Nocturnal hawkmoths are known for impressive visually guided behaviours in dim light, such as hovering while feeding from nectar-bearing flowers. This requires tight visual feedback to estimate and counter relative motion. Discrimination of low velocities, as required for stable hovering flight, is fundamentally limited by spatial resolution, yet in the evolution of eyes for nocturnal vision, m...

The HandySinger system is a personified tool developed to naturally express a singing voice controlled by the gestures of a hand puppet. Assuming that a singing voice is a kind of musical expression, natural expressions of the singing voice are important for personification. We adopt a singing voice morphing algorithm that effectively smoothes out the strength of expressions delivered with a si...

Cyclin E together with its kinase partner Cdk2 is a critical regulator of entry into S phase. To identify novel genes that regulate the G1- to S-phase transition within a whole animal we made use of a hypomorphic cyclin E mutation, DmcycEJP, which results in a rough eye phenotype. We screened the X and third chromosome deficiencies, tested candidate genes, and carried out a genetic screen of 55...

Objective: To ascertain whether the quality of physician-patient communication makes a significant difference to patient health outcomes. Data sources: The MEDLINE database was searched for articles published from 1983 to 1993 using "physician-patient relations" as the primary medical subject heading. Several bibliographies and conference proceedings were also reviewed. Study selection: Randomi...

A method for string alignment is presented in which a moiré technique is applied to one-dimensional spatial encoding patterns. String alignment, an essential operation in genome analysis, evaluates local similarity between sequences of bases or amino acids. The method uses a simple procedure to provide matching results for not only the same locus but also neighboring loci. Experimental verifica...