Objective: To identify the trends of red cell alloimmunization in multi-transfused females using blood panels.Study design: Cross-sectional study.
 Place and Duration Study: Army Medical College Armed Forces Institute Transfusion with collaboration Pak Emirates Military Hospital, Rawalpindi Pakistan, from Jan to Aug 2018.
 Methodology: Blood samples 75 prior history transfusion were c...

The recipient and donor mechanisms responsible for mediating alloimmunity and immunomodulation during blood transfusions are complex and most probably superimposed thus creating multilevel fields of potential interaction and regulation. For example, at the recipient level, both the innate and adaptive immune systems can be significantly affected by various types of transfusions [1,2]. In additi...

The use of transfusion therapy for sickle cell disease (SCD) is increasing due to expanded indications, increased availability of erythrocytapheresis, and oral chelators to treat transfusional iron overload. However, alloimmunization to red blood cell (RBC) blood group antigens remains a major complication for patients with SCD and often presents significant challenges in their medical manageme...

ORTHOTOPIC LIVER transplantation (OL T) is often accompanied by massive blood loss due to portal hypertension, difficult dissection as a result of previous abdominal surgery. and coagulation abnormalities. Major alterations of the coagulation factors such as prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT). decreased fibrinogen levels and thrombocytopenia have al...

BACKGROUND Red blood cell (RBC) alloimmunization is still an actual problem in our transfusion practice. In 2011, in addition to the regular ABO/D blood group typing, phenotyping for Rh (C, c, E, e) and Kell antigens was introduced for blood donors and patients undergoing blood transfusion. Our aim was to evaluate the impact of the extended RBC typing and donor/recipient matching on the inciden...

BACKGROUND Red blood cells (RBCs) undergo changes during storage. Various studies have suggested a higher risk of adverse and often multifactorial clinical outcomes associated with older-stored RBCs. Our aim therefore was to examine if storage of transfused RBCs is also associated with the risk of RBC-specific alloantibody formation. STUDY DESIGN AND METHODS A two-center retrospective case-re...

OBJECTIVE The purpose of this study was to determine the most cost-effective option to prevent alloimmunization against the Rh factor. METHODS A virtual population of Rh-negative pregnant women in Quebec was built to simulate the cost-effectiveness of preventing alloimmunization. The model considered four options: (1) systematic use of anti-D immunoglobulin; (2) fetal Rh(D) genotyping; (3) im...

Twenty-four percent of sickle cell disease (SCD) patients have a stroke by the age of 45 years. Blood transfusions decrease stroke risk in patients deemed high risk by transcranial Doppler. However, transcranial Doppler has poor specificity, and transfusions are limited by alloimmunization and iron overload. Transfusion withdrawal may be associated with an increased rebound stroke risk. Extende...

RH genes are highly polymorphic and encode the most complex of the 35 human blood group systems. This genetic diversity contributes to Rh alloimmunization in patients with sickle cell anemia (SCA) and is not avoided by serologic Rh-matched red cell transfusions. Standard serologic testing does not distinguish variant Rh antigens. Single nucleotide polymorphism (SNP)-based DNA arrays detect many...