Rationale: Heme oxygenase (HO)1 is an important modulator of physiological function with cytoprotective properties. Although HO1 has previously been associated with an improved survival of the vascular allograft in rat models in response to pharmaceutical induction of HO1 the exact mechanism by which HO1 exerts it protective function remains to be elucidated. Objective: We sought to define the ...

BACKGROUND Subcutaneous phaeohyphomycosis in solid organ recipients may have an adverse outcome. OBJECTIVE We sought to describe the disease course, treatment, and outcome of allograft function in kidney transplant recipients with phaeohyphomycosis. METHODS Seventeen patients were followed for a mean period of 25.4 months to analyze the clinical response to treatment. RESULTS There was no...

BACKGROUND Few medium-term or long-term reports on meniscal allograft transplantations are available. In this study, we present the results of a survival analysis of the clinical outcomes of our first 100 procedures involving transplantation of viable medial and lateral meniscal allografts performed in ninety-six patients. METHODS Thirty-nine medial and sixty-one lateral meniscal allografts w...

Significant progress has been made in preventing acute allograft rejection following solid organ transplantation resulting in improved allograft survival. However, long term function still remains disappointing primarily due to chronic allograft rejection. Alloimmune responses primarily defined by the development of antibodies (Abs) to donor mismatched major histocompatibility antigens during t...

The development of cardiac allograft vasculopathy remains the Achilles heel of cardiac transplantation. Unfortunately, the definitions of cardiac allograft vasculopathy are diverse, and there are no uniform international standards for the nomenclature of this entity. This consensus document, commissioned by the International Society of Heart and Lung Transplantation Board, is based on best evid...

Kidney transplant recipients may develop chronic allograft failure due to immune and non-immune mechanisms, including chronic rejection, nephrotoxicity from calcineurin inhibitors, recurrent glomerular disease, BK viral infection and uncommon causes. We report two patients with chronic deterioration of graft function after combined kidney and pancreas allograft transplantation who presented wit...

Rationale: Heme oxygenase (HO)1 is an important modulator of physiological function with cytoprotective properties. Although HO1 has previously been associated with an improved survival of the vascular allograft in rat models in response to pharmaceutical induction of HO1 the exact mechanism by which HO1 exerts it protective function remains to be elucidated. Objective: We sought to define the ...

Chronic allograft nephropathy is the major cause of kidney allograft loss, and recent advances in immunosuppression therapy do not alter the picture. Interstitial fibrosis and tubular atrophy is an early event that starts early after engraftment and even could be found in recipients with good allograft function. Serum creatinine and estimated glomerular filtration rate have limited clinical rol...

Renal biopsy remains the "gold standard" for the diagnosis of renal allograft dysfunction. The aim of our study was to highlight the importance of renal biopsy in the management of allograft dysfunction (early diagnosis and therapeutic approach). Our study included 23 renal allograft biopsies from 20 patients. This retrospective study analyzed the demographic and clinical data, histological res...

INTRODUCTION: The tendon graft still plays an important role to restore hand function if the damaged tendon can not be directly repaired, or if a primary repair fails. Animal studies have shown that intrasynovial tendon autografts result in better functional restoration compared with extrasynovial tendon autografts, but the availability of intrasynovial autograft tendons is limited. Previous wo...