Pathogenic memory T cells are implicated in the local relapse of allergic contact dermatitis (ACD), vitiligo and psoriasis. Here we investigate how resident initiate relapses response to allergen Methylisothiazolinone (MI). MI–related ACD was sampled two months years after resolution disease. were activated skin explants with MI or pan T-cell agonist OKT-3. Epidermis analysed by RNAseq, Nanostr...

Allergic contact dermatitis (ACD) of the hands can be a frustrating and underdiagnosed condition. While plant based products are a common source of ACD, tea leaves have rarely been reported as a cause of dermatitis. We describe a case of contact dermatitis from Pu-erh black tea as a result of chronic handling of tea leaves. Patch testing of both the patient and 6 normal controls helped to ident...

Background: Job-related allergic contact dermatitis (ACD) mayprolong the disease duration, increase disabilities, and decreasethe patient’s quality of life. The aim of this study was to determinecommon allergens causing ACD, investigating certain featuresof the disease and evaluating its relation to the patients’ jobs.Method: In this cross-sectional study, relevant data was obtainedfrom patch t...

Background. Increasing use of cosmetics has contributed to a rise in the incidence of allergic contact dermatitis (ACD) to cosmetics. It is estimated that 1-5.4% of the population is sensitized to a cosmetic ingredient. Patch testing helps to confirm the presence of an allergy and to identify the actual allergens which are chemical mixtures of various ingredients. Objectives. The aims of this s...

Pustular allergic contact dermatitis (ACD) is rare, with reactions to the topical antibacterial nitrofurazone (1), isoconazole nitrate (2), topical minoxidil 2% (3), 1% fluorouracil (4), black rubber (5) and tricholoroethylene (6) having been reported. The clinical appearance of pustular ACD has been reported to comprise multiple small pustules, only 0.5–1mm in size, on a background of erythema...

Nitric oxide (NO) is involved in the pathogenesis of acute and chronic inflammatory conditions, namely in allergic contact dermatitis (ACD). However, the mechanism by which NO acts in ACD remains elusive. The present study focuses on the effects of different contact sensitizers (2,4-dinitrofluorbenzene, 1,4-phenylenediamine, nickel sulfate), the inactive analogue of DNFB, 2,4-dichloronitrobenze...

Allergic contact dermatitis (ACD) is one of the most common inflammatory skin diseases, which is classified as a delayed-type hypersensitivity immune response. The development of ACD is divided into two phases: sensitization and elicitation. In the sensitization phase, antigen-specific effector T cells are induced in the draining lymph nodes by antigen-captured cutaneous dendritic cells (DCs) t...

BACKGROUND Allergic contact dermatitis (ACD) is an inflammatory skin disease caused by repeated skin exposure to contact allergens. The goal of this pilot study was to identify inflammatory proteins which can serve as biomarkers for ACD. METHODS We measured levels of 102 cytokines, chemokines, and growth factors in the sera of 16 ACD patients during acute and remission phases, and 16 healthy ...

Allergic contact dermatitis (ACD) is a diagnosis that requires significant patient education for proper management. There limited information regarding satisfaction. We aimed to assess satisfaction among adults in the United States with ACD. Data from 2016-2019 Medical Expenditure Panel Survey was analyzed. Comparing ACD (n=119) control group of without (n=86,291), those trended toward higher r...

INTRODUCTION Although Mercromina Film and other topical antiseptics are widely used, they are not included in the standard series recommended by the Spanish Contact Dermatitis and Skin Allergy Research Group for testing suspected allergic contact dermatitis (ACD). Furthermore, no recent studies have investigated the allergenic potential of merbromin. OBJECTIVE To determine the allergenic pote...