Single-electron transmetalation via photoredox/nickel dual catalysis provides the opportunity for the construction of Csp(3)-Csp(2) bonds through the transfer of alkyl radicals under very mild reaction conditions. A general procedure for the cross-coupling of primary and secondary (bis-catecholato)alkylsilicates with alkenyl halides is presented. The developed method allows not only alkenyl bro...

Decarboxylative cross-coupling of alkyl carboxylic acids with vinyl halides has been accomplished through the synergistic merger of photoredox and nickel catalysis. This new methodology has been successfully applied to a variety of α-oxy and α-amino acids, as well as simple hydrocarbon-substituted acids. Diverse vinyl iodides and bromides give rise to vinylation products in high efficiency unde...

Abstract Pd-catalyzed direct arylation of 2-alkylthiazoles is a well-known reaction affording the corresponding 2-alkyl-5-arylthiazoles in very high yields. Conversely, reactivity 2-alkoxythiazoles has not been described yet. Herein, we report conditions for regioselective C5-arylation 2-alkoxythiazoles. Moreover, also found leading to 3-alkyl-5-arylthiazol-2(3H)-ones via one-pot with an O- N-a...

A group of biodegradable alanine-derived gemini quaternary ammonium salts (bromides and chlorides) with various alkyl chains and spacer lengths was tested for anti-adhesive and anti-biofilm activity. The strongest antifungal activity was exhibited by bromides with 10 and 12 carbon atoms within hydrophobic chains (N,N'-bis(1-decyloxy-1-oxopronan-2-yl)-N,N,N',N'-tetramethylpropane-1,3-diammonium ...

Twelve different lipophilic organic cations (tetraethyl-, tetrapropyl-, tetrabutyl-, tetrapentyl-, tetrahexyl-, tetraheptyl-, decyltrimethyl-, cetyltrimethyl-, and benzyltriethylammonium bromides; and dibenzyldimethylammonium chloride, N-1-dodecylnicotinamide chloride, and cetylpyridinium bromide) depressed respiratory control in rat liver mitochondria. Evaluation of mitochondrial responses in ...