The Silver nanoparticles are well-known for their antimicrobial, anti-inflammatory wound healing abilities. We synthesized Silver nanoparticles using chemical reduction method and the formation of the silver nanoparticles was characterized by UV-Vis absorption spectroscopy, FT-IR and SEM techniques. The minimum inhibitory concentration of the synthesized nanoparticles was determined for both gr...

Hydrogels can promote desirable cellular phenotype by mimicking tissue-like stiffness or serving as a gene delivery depot. However, nonviral gene delivery inside three-dimensional (3D) hydrogels remains a great challenge, and increasing hydrogel stiffness generally results in further decrease in gene delivery efficiency. Here we report a method to enhance nonviral gene delivery efficiency insid...

Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fluid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe3O4) nanoparticles as the core, organic alginate as the shell...

In the current study, facile synthesis of carboxymethyl cellulose (CMC) and sodium alginate capped silver nanoparticles (AgNPs) was examined using microwave radiation and aniline as a reducing agent. The biopolymer matrix embedded nanoparticles were synthesized under various experimental conditions using different concentrations of biopolymer (0.5, 1, 1.5, 2%), volumes of reducing agent (50, 10...

The era of nanotechnology has allowed new research strategies to flourish in the field of drug delivery. Nanoparticle-based drug delivery systems are suitable for targeting chronic intracellular infections such as tuberculosis. Polymeric nanoparticles employing poly lactide-co-glycolide have shown promise as far as intermittent chemotherapy in experimental tuberculosis is concerned. It has dist...

Nanoformulation consisting of Streptomycin loaded chitosan-alginate nanoparticles were prepared using ionotropic-pregelation method and optimization was done in terms of polymer concentration, crosslinker concentration and stirring time. The optimal parameters were found to be Chitosan 0.75mg/ml, calcium chloride 1% (w/v) and stirring time 90 min. Polymer (chitosan and sodium-alginate) and cros...

Silver nanoparticles are gaining importance as an antimicrobial agent in wound dressings. Chitin is a biopolymer envisioned to promote rapid dermal regeneration and accelerate wound healing. This study was focused on the evaluation of chitin membranes containing silver nanoparticles for use as an antimicrobial wound dressing. Silver nanoparticles were synthesised by gamma irradiation at doses o...

Restricted self-recovery that pursues a bone injury and the need of inexpensive painless clinical treatments for tissue regeneration require new pathways developments to fabricate biocompatible biodegradable scaffolding materials. For these requirements, covalent crosslinked alginate alginate/Mg-doped hydroxyapatite (MgHAp) hydrogels are fabricated by “click” chemistry mimic highly porous struc...

background: current anti-cancer drug therapy results in systemic side effects due to non-specific uptake by normal healthy noncancerous tissues. to alleviate this difficulty, many attempts have been devoted to the development of new delivery systems such as polymeric nanoparticles (nps). in this study, we prepared icd-85 nps based on sodium alginate and analyzed the cytotoxic activity of icd-85...

Magnetic resonance imaging (MRI)-visible amonafide-eluting alginate microspheres were developed for targeted arterial-infusion chemotherapy. These alginate microspheres were synthesized using a highly efficient microfluidic gelation process. The microspheres included magnetic clusters formed by USPIO nanoparticles to permit MRI and a sustained drug-release profile. The biocompatibility, MR imag...