The report before us is of the greatest interest. It contains valuable mortuary statistics from the foundation of the Society up to 1874. Since the Society has been formed, the total number of persons assured amounts to 101,967, out of which number 5,385 have died. The minutest detail is entered into with reference to the deaths occurring in the various states, with special allusion to the epid...

To determine the prevalence and spectrum of alcohol-related diseases in a general hospital inpatient population, data of 1288 patients newly admitted to a city general hospital, who had been examined with regards to alcoholism, were surveyed. The sample consisted of 625 medical and 663 surgical patients aged 18-64 years. In 21% (29.3% of the men and 9.4% of the women), inpatient treatment was d...

Sir: Gabapentin is one of a new generation of antiepileptic drugs widely used in recent years for a variety of indications, including epilepsy, neuropathic pain, migraine, and bipolar disorder. Although gabapentin is structurally analogous to γ-aminobutyric acid (GABA), it does not appear to affect GABA uptake or the GABA A or GABA B receptors. The basis of its anticonvulsant efficacy is unclea...

AIMS AND METHODS Alcohol withdrawal treatment efficacy of tiapride/carbamazepine (A) vs clomethiazole (B) vs diazepam (C) in non-intoxicated patients and vs tiapride/carbamazepine in intoxicated patients (D; breath alcohol concentration > or = 1 g/l) was tested (n = 127) in a controlled randomized open-label study. RESULTS Efficacy and safety were not different between groups (total group: de...

Symptoms of alcohol withdrawal syndrome (AWS) may develop within 6-24 h after the abrupt discontinuation or decrease of alcohol consumption. Symptoms can vary from autonomic hyperactivity and agitation to delirium tremens. The gold-standard treatment for AWS is with benzodiazepines (BZDs). Among the BZDs, different agents (i.e., long-acting or short-acting) and different regimens (front-loading...

AIMS To compare the clinical course, incidence of withdrawal seizures (WS) or delirium tremens (DT) and side effects during treatment of alcohol withdrawal in patients treated with either carbamazepine (CBZ) or valproate (VPA) as an adjunct to clomethiazole and clonidine therapy. METHODS Retrospective analysis of charts of two cohorts of inpatients treated during 2000-2009: CBZ 374 patients, ...

AIMS To develop a prediction model for withdrawal seizures (WS) and delirium tremens (DT) during moderate to severe alcohol withdrawal syndrome (AWS) in a large cohort of inpatients treated for AWS (n = 827). METHODS Re-analysis of a cohort study population treated between 2000 and 2009. All patients received a score-guided and symptom-triggered therapy for AWS. Multivariable binary logistic ...

Introduction Delirium tremens is one of the most serious complications associated with alcohol withdrawal. It affects a percentage 5 to 20% users and not related duration consumption nor quantities taken. An early diagnosis will facilitate quick treatment without putting at risk vital prognosis. Objectives Our objective identify different indicators mentioned in existing literature compare thes...