background: complications of ventolin as the most common drug used for bronchiolitis are widely known. the present study was conducted to determine the efficacy of hypertonic saline 3%, compared with ventolin, for treatment of acute bronchiolitis in children.   methods : this double-blinded clinical trial study was conducted in hajar hospital, shahrekord, iran, from 2011 to 2012. a total of 70 ...

Airway epithelial NF-κB activation is observed in asthmatic subjects and is a cause of airway inflammation in mouse models of allergic asthma. Combination therapy with inhaled short-acting β2-agonists and corticosteroids significantly improves lung function and reduces inflammation in asthmatic subjects. Corticosteroids operate through a number of mechanisms to potently inhibit NF-κB activity. ...

BACKGROUND In-line administration of bronchodilators is widely used in pediatric patients receiving mechanical ventilation. We compared the amount of albuterol captured at the end of the endotracheal tube (ETT) with an intrapulmonary percussive ventilator (IPV) versus a Salter 8900 jet nebulizer placed in-line in a pediatric ventilator model, under various operating conditions. We hypothesized ...

The propellant-free Combivent Respimat Soft Mist Inhaler (CVT-R) was developed to replace the chlorofluorocarbon-propelled Combivent metered-dose inhaler (CVT-MDI). This steady-state pharmacokinetic (PK) substudy evaluated drug lung-delivery efficiency, using data from two phase III safety and efficacy trials. PK parameters were obtained from well-controlled population PK analyses. Area under t...

OBJECTIVES Continuous albuterol nebulization is generally administered at 2.5-20 mg/hr at most centers. We examined the effect of high-dose (75 or 150 mg/hr) albuterol on clinical variables in children with status asthmaticus. DESIGN Retrospective analysis of inpatient medical records and prospectively collected computerized PICU respiratory therapy database. SETTING Twenty-five-bed multidi...

We were interested by the possible association between the control serum K levels and maximum decrease in serum K after 3,-adrenergic drug administration described by Raimondi et al. When we re-examined our data in this light there was no linear correlation found in the group that received IM albuterol (r = . 10), a weak correlation in the IV albuterol group (r .50) and a good linear correlatio...

BACKGROUND Accurate tracking of the administered dose of asthma rescue inhalers is critical for optimal disease management and is related to reductions in rates of unscheduled health care utilization in asthma patients. There are few published data on the real-world impact of rescue inhalers with integrated dose counters (IDCs) on health care resource utilization (HRU) for asthma patients. This...

STUDY OBJECTIVE To use histamine bronchoprovocation and bioassay statistical procedures to evaluate the in vivo bioequivalence of a generic albuterol metered-dose inhaler (MDI). DESIGN A randomized, double-blind, balanced, crossover design was used to determine the potency of each generic albuterol MDI actuation relative to Ventolin (Glaxo Wellcome; Research Triangle Park, NC) administration....

OBJECTIVE To determine the amount of albuterol, in various particle size ranges, delivered from a hydrofluoroalkane-propelled metered-dose inhaler (Airomir) in 3 models of pediatric intubation (ages 8 months, 4 years, and 16 years) using 4 types of aerosol reservoir: 3 spacers (ACE, AeroChamber HC MV, metal NebuChamber without 1-way valve) and 1 holding chamber (metal NebuChamber with 1-way val...

Albuterol is an uncommonly recognized culprit in causing lactic acidosis. While treating asthmatics, lactic acidosis creates a paradoxical situation in which, despite improvement in bronchospasm, patients look more dyspneic as a compensatory mechanism for metabolic acidosis. This might lead to misinterpretation of the situation with increased albuterol dosing, creating a sort of vicious cycle u...