Objective(s): The aim of this study was to investigate the effect of curcumin on the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) and its underlying potential mechanism.Materials and Methods: The tissue explant adherence method was used to isolate hPDLSCs. Flowcytometry, Alizarin Red staining and Oil Red ...

A serine/threonine-specific protein kinase B (PKB), also known as Akt, is a key factor in the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway that regulates cell survival, metabolism and proliferation. Akt phosphorylates many downstream specific substrates, which subsequently control nuclear envelope breakdown (NEBD), centrosome maturation, spindle assembly, chromosome segregation, cytok...

Objective(s): We previously reported a series of quinazoline derivatives as vascular-targeting anticancer agents. In this study, we investigated the mechanism underlying the anti-angiogenic activity of the quinazoline derivative compound 11d. Materials and Methods: We examined the effects of quinazoline derivative 11d on vascular endothelial growth factor receptor-2 (VEGFR2) activation via VEG...

Objective(s): Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression. A line of evidences revealed that LPS induces autophagy in cardiomyocytes injury. This study aims to evaluate the effects of eupafolin on LPS-induced cardiomyocyte autophagy...

Introduction Thyroid cancer is a malignant disease with poor prognosis. The PI3K/Akt/mTOR and Cyclin-Dependent Kinase 4 (CDK4) pathways are vital regulators of tumor cell proliferation and survival. Therefore the present study was designed to use dual inhibition of such pathways to kill thyroid cancer cells. Methods and materials The effects of each inhibitors on human ATC and...

Purpose: To investigate the effect of emodin on osteosarcoma cell proliferation and apoptosis.
 Methods: The ability was determined by CCK-8, apoptosis level cycle were via flow cytometry. Honechst staining used to determine ratio nuclear pyknosis, Western blotting expression AKT, p-AKT caspase-3 precursor protein in each group cells.
 Results: Emodin significantly inhibited MG-63 pro...

Background Puerarin demonstrates a protective effect in many cardiovascular diseases. However, the role of puerarin acute myocardial infarction (AMI)-induced injury and exact molecular mechanisms are not fully understood. Objectives To investigate whether pretreatment improves cardiac function to study mechanism action puerarin. Material methods Thirty rats were grouped into sham group, AMI gro...

Background Liver cancer is a common threat to human health. Schizandrin A (SA) has certain therapeutic effect on liver cancer, but its related mechanism of action not clear. Elucidating this great significance for the development drugs target cancer. Objective The objective study and SA Methods potential targets in treatment were screened based network pharmacology, core further by protein inte...

Marein is the main active substance of Coreopsis tinctoria nutt. It not only has anti-oxidation and anti-tumor effects, but also can lower blood lipid, prevent high glucose, improve insulin resistance, inhibit gluconeogenesis promote glycogen synthesis. However, exact mechanism its action still unclear. Here, we explored effect on resistance. The mice were divided into db/m, db/db, metformin+db...