Adenylate kinase (AK) modulates the interconversion of adenine nucleotides (AMP + adenosine triphosphate----2 ADP). We evaluated the fifth kindred with hereditary erythrocyte (RBC) AK deficiency. The proband had chronic hemolytic anemia. Her RBC had undetectable AK activity when measured spectrophotometrically, whereas those of her parents had half-normal AK activity. AK electrophoresis showed ...

Let K = {K0, ...,Kk} be a family of convex bodies in R , 1 ≤ k ≤ n−1. We prove, generalizing results from [9], [10], [13], [14], that there always exists an affine k-dimensional plane Ak ⊆ R , called a common maximal k-transversal of K, such that for each i ∈ {0, ..., k} and each x ∈ R Vk(Ki ∩Ak) ≥ Vk(Ki ∩ (Ak + x)), where Vk is the k-dimensional Lebesgue measure in Ak and Ak + x. Given a famil...

A panel of mutant class II genes have been constructed using site-directed mutagenesis and DNA-mediated gene transfer. Using this technique, Ak beta polypeptides have been altered by substituting one or more Ad beta-specific residues at polymorphic positions in the beta 1 domain. Transfection of M12.C3 B lymphoma cells with most mutant Ak beta* genes results in the expression of Ak beta* Ad alp...

Harbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USA Geophysical Institute, University of Alaska, Fairbanks, AK 99708, USA Department of Wildlife Management, North Slope Borough, Barrow, AK 99723, USA Alaska Department of Fish and Game, Fairbanks, AK 99701, USA Native Village of Kotzebue, Kotzebue, AK 99752, USA Alaska Beluga Whale Committee, Barrow, AK...

Neben der Funktionalität finden Qualitätsattribute wie Sicherheit, Gebrauchstauglichkeit, Performanz und Zuverlässigkeit in verschiedensten Domänen immer mehr Beachtung. Das Vernachlässigen dieser Qualitäten führt häufig zu gescheiterten Projekten, verlängerter Time To Market und hohem Änderungsaufwand. Wie können jedoch im Requirements Engineering nichtfunktionale Anforderungen effizient erhob...

We show that if the space `∞/c0 contains an isometric copy of every function space over a first countable compactum or every function space over a Corson copactum of weight not exceeding the continuum then every subset of R belongs to the σfield generated by sets of the form A1×A2.We prove a similar result about isomorphic rather than isometric embeddings into `∞/c0 in terms of the σ-field of s...

The semiclassical motion of electrons in phase space x = (R,k) is influenced by Berry phases described by a six-component vector potential A = (AR,Ak). In chiral magnets, Dzyaloshinskii-Moriya (DM) interactions induce slowly varying magnetic textures (helices and skyrmion lattices) for which all components of A are important, inducing effectively a curvature in mixed position and momentum space...

Ingenol mebutate (IM) is a topical pharmacotherapy approved in Switzerland since 2012 for treating non-hypertrophic, non-hyperkeratotic actinic keratosis (AK). We report 2 cases with off-label use of IM. The first case of bowenoid AK was treated with 150 μg IM for 3 consecutive days with an almost complete clinical remission of the lesion. The second case of Bowen's disease was treated with 500...