The absolute configuration of (+)-2,7(14),10-bisabolatrien-1-ol-4-one, a peculiar sesquiterpenol in the Japanese cedar, Cryptomeria japonica, was determined as (1S,6R)-2,7(14),10-bisabolatrien-1-ol-4-one by comparing the specific rotation values of cryptomeriones respectively converted from (+)-2,7(14),10-bisabolatrien-1-ol-4-one and synthesized from (R)-(-)-carvone.

A highly sensitive and selective high-performance liquid chromatography (HPLC) method was developed for the determination of doxorubicin (DXR) and its metabolite doxorubicinol (DXR-ol) in rat plasma. The method was based on photosensitization reaction followed by peroxyoxalate chemiluminescence detection (PO-CL). DXR and DXR-ol that were fluorescent quinones, served as a photosensitizer in the ...

There are two categories in which educator can deliver open distance learning (ODL) via an internet connection, namely Synchronous Online Learning (OL-sync) and Asynchronous (OL-async). At Universiti Teknologi MARA Cawangan Pulau Pinang (UiTMCPP), lecturers could conduct ODL OL-sync or OL-async due to MCO was enforced on March 18, 2020. Therefore, this study conducted compare the influence of d...

In several application domains (detection systems, telecommunications, video processing, etc.) the applications deal with multidimensional data. These applications are usually embedded and subjected to real-time and resource constraints. The challenge is thus to provide efficient implementations on parallel and distributed architectures. Array-OL has been designed specifically to handle this ki...

Neher and Wettstein (1) have recently published the details of a paper chromatographic method for the separation of weakly polar steroids, with a heptane-phenyl Cellosolve solvent system. Savard (2) has described the separation of 17-ketosteroids on paper with ligroin as the mobile phase and propylene glycol as the stationary phase. Starting from the basic work of these authors, a method has be...

BACKGROUND Though on-line intermittent hemodiafiltration (OL-IHDF) is a routine therapy for chronic dialysis patients, it is not yet widespread used in critically ill patients. This study was undergone to evaluate efficiency and tolerance of OL-IHDF and to appreciate inflammatory consequences of its use in intensive care unit (ICU)-acute kidney injury (AKI) patients. METHODS In this prospecti...

Oligodendrocyte (OL) differentiation and myelin development are complex events regulated by numerous signal transduction factors. Here, we report that phosphoinositide-3 kinase enhancer L (PIKE-L) is required for OL development and myelination. PIKE-L expression is up-regulated when oligodendrocyte progenitor cells commit to differentiation. Conversely, depleting phosphoinositide-3 kinase enhan...

Six nitrogen-, sulfur- and cyclopropane-containing derivatives of cholestanol were examined as inhibitors of growth and sterol biosynthesis in the trypanosomatid protozoan Crithidia fasciculata. The concentrations of inhibitors in the culture medium required for 50% inhibition of growth were 0.32 microM for 24-thia-5 alpha,20 xi-cholestan-3 beta-ol (2), 0.009 microM for 24-methyl-24-aza-5 alpha...