The targeted delivery of nanoparticle carriers holds tremendous potential to transform the detection and treatment of diseases. A major attribute of nanoparticles is the ability to form multiple bonds with target cells, which greatly improves the adhesion strength. However, the multivalent binding of nanoparticles is still poorly understood, particularly from a dynamic perspective. In previous ...

OBJECTIVE To evaluate the efficacy of subconjunctival nanoparticle carboplatin in the treatment of transgenic murine retinoblastoma. METHODS Dendrimeric nanoparticles loaded with carboplatin were prepared. Forty LHbeta-Tag mice were randomly assigned into 4 groups and treated at 10 weeks of age. Each mouse received a single subconjunctival injection in one eye, and the opposite eye was left u...

Using classical density functional theory, the structure of a molecular fluid around a cylindrical nanoparticle near a solid substrate is studied. The solvent-mediated force between the nanoparticle and the substrate is calculated in both the nematic and isotropic phases of the solvent. In the nematic phase, the force is short ranged and arises due to interaction between high-density regions ne...

Nanoparticle exposure in pregnancy may result in placental damage and fetotoxicity; however, the factors that determine fetal nanoparticle exposure are unclear. Here we have assessed the effect of gestational age and nanoparticle composition on fetal accumulation of maternally-administered nanomaterials in mice. We determined the placental and fetal uptake of 13 nm gold nanoparticles with diffe...

A new route for tailoring the behavior of colloidal suspensions through nanoparticle additions is reviewed. Specifically, the interparticle interactions, phase behavior, 3-D structure, and rheological properties of microsphere–nanoparticle mixtures that possess both high charge and size asymmetry are described. Negligibly charged microspheres, which flocculate when suspended alone, undergo a re...

Cu2ZnSnS4 nanoparticle with an average diameter of approximately 31 nm has been successfully synthesized by a time effective microwave fabrication method. The crystal structure, surface morphology, and microstructure of the Cu2ZnSnS4 nanoparticle were characterized. Moreover, the visible light photocatalytic ability of the Cu2ZnSnS4 nanoparticle toward degradation of methylene blue (MB) was als...

Nanoparticle coated microspheres are composed of two or more materials with a core/shell structure and exhibit unique abilities that allow amplification of trace targets in immunoassays. The preparation of nanoparticle coated microspheres can be accomplished using three main strategies: (1) in-situ, (2) ex-situ, and (3) hollow sphere methods. Antibodies or biomolecules can be immobilized on the...

A derivation of chemical equilibrium equations for a spherical thin film of solution around a soluble solid nanoparticle is presented. The equations obtained generalize the Gibbs-Kelvin-Kohler and Ostwald-Freundlich equations for a soluble particle immersed in the bulk phase. The generalized equations describe the dependence of the chemical potentials of a condensate and dissolved nanoparticle ...

We demonstrate focusing coherent light on a nanoparticle through turbid media based on digital optical phase conjugation of second harmonic generation (SHG) field from the nanoparticle. A SHG active nanoparticle inside a turbid medium was excited at the fundamental frequency and emitted SHG field as a point source. The SHG emission was scattered by the turbid medium, and the scattered field was...

We employ a novel Monte Carlo simulation scheme to elucidate the stabilization of neutral colloidal microspheres by means of highly charged nanoparticles [Proc. Natl. Acad. Sci. U.S.A. 98, 8950 (2001))]]. In accordance with the experimental observations, we find that small nanoparticle concentrations induce an effective repulsion that prevents gelation caused by the intrinsic van der Waals attr...