In developmental biology, modeling and simulation play an important role in understanding cellular interactions. We suggest a simple language, the Cell Programming Language (CPL), to write computer programs to describe this behavior. Using these programs, it is possible to simulate and visualize intercellular behavior. We employ CPL to model aggre-gation in Dictyostelium in response to a chemot...

Locusts are infamous for their ability to aggregate into gregarious migratory swarms that pose a major threat to food security. Aggregation is elicited by an interplay of visual, tactile, and chemical stimuli, but the aggregation pheromone in feces is particularly important. Infection by the microsporidian parasite Paranosema (Nosema) locustae is known to inhibit aggregation of solitary Locusta...

In this paper, the effects of carbon nanotube (CNT) orientation and aggregation on the static behavior of functionally graded nanocomposite cylinders reinforced by CNTs are investigated based on a mesh-free method. The used nanocomposites are made of the straight CNTs that are embedded in an isotropic polymer as matrix. The straight CNTs are oriented, randomly or aligned or local aggregated int...

Organized assembly or aggregation of sphingolipid-binding ligands, such as certain toxins and pathogens, has been suggested to increase binding affinity of the ligand to the cell membrane and cause membrane reorganization or distortion. Here we show that the diffusion behavior of the fluorescently tagged sphingolipid-interacting peptide probe SBD (Sphingolipid Binding Domain) is altered by modi...

Peptide-mimicking scaffolds with an incorporated ester-urea motif, replacing two adjacent amide residues, were synthesized and their aggregation behavior was studied in dependence of hydrogen bonding sites as well as backbone stereochemistry. Two oligomer series containing either 50% or 100% ester-urea units and either all-(l) or (d)-alt-(l) backbone configuration were prepared via ester and am...

while ignoring income distribution and estimating aggregate demand generally leads to aggregation bias and thus, does not reflect households’ demand properly, yet aggregation bias is rarely considered in empirical demand studies and simply is ignored in most cases. the objective of the present study is to estimate aggregation bias in households’ demand for various types of meats and to evaluate...

protein aggregation is a serious problem for both biotechnology and cell biology. diseases such as prion misfolding, alzheimer’s, and other amyloidosis are phenomena for which protein aggregation in our living cells is of considerable relevance. human lysozyme has been shown to form amyloid fibrils in individuals suffering from nonneuropathic systemic amyloidosis, all of which have point mutati...

a series of novel 2-aminopyrimidine and 2-substituted-4,6-diaminopyrimidine derivatives have been synthesized and their anti platelet aggregation activities were assessed against adp and arachidonic acid- induced platelet aggregation in human plasma using light transmission aggregometry. none of the compounds showed satisfactory activity against the aggregation induced by adp. however, satisfac...